Results 61 to 70 of about 142,687 (264)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Deformation and Resistivity Characteristics of Compacted Loess Under Dry–Wet Cycles

Geosciences
Compacted loess is widely used as road subgrade filling in northwestern China, but its stability is threatened by traffic loads and repeated dry–wet cycles, leading to subgrade settlement or collapse.
Peng Li, Zichuan Wang, Yuqi Liu, Jiaxin Yang, Xiao Zhang, Zemin Xue, Dongtun Hao, Pengju Qin   +7 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Improved Grammar-Based Compressed Indexes [PDF]

, 2012
We introduce the first grammar-compressed representation of a sequence that supports searches in time that depends only logarithmically on the size of the grammar. Given a text $T[1..u]$ that is represented by a (context-free) grammar of $n$ (terminal and nonterminal) symbols and size $N$ (measured as the sum of the lengths of the right hands of the ...
Claude, Francisco, Navarro, Gonzalo
openaire   +4 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Sustainable prediction of compression index in fine-grained soils using machine learning techniques

Open Geosciences
The accurate prediction of ultimate settlement is of critical importance for the longevity of structures, as it helps prevent structural damage and functional deterioration.
İmamoğlu Tuncay, Sert Sedat, Bol Ertan, Özocak Aşkın, Arslan Eylem, Bağca İrem, Kocaman Kadir, Özsağır Mustafa, Akmaz Emre   +8 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

About Graph Index Compression Techniques [PDF]

, 2019
We perform a preliminary study on large graph efficient indexing using a gap-based compression techniques and different node labelling functions. As baseline we use the Webgraph + LLP labelling function. To index the graph we use three labelling functions: Pagerank, HITS, and Pagerank with random walks choosing restart nodes with HITS authority scores.
Antonio Cruciani, Daniele Pasquini, Giambattista Amati, Vocca P   +3 more
openaire   +4 more sources

Heterogeneidade da compactação de um latossolo vermelho-amarelo sob pomar de laranja Compaction heterogeneity of a haplustox under an orange orchard

Revista Brasileira de Ciência do Solo, 2004
A heterogeneidade na compactação do solo, provocada por diferentes intensidades de tráfego, pode limitar a produção em áreas citrícolas. O objetivo deste trabalho foi quantificar o índice de compressão (IC) e a pressão de preconsolidação (sigmap) nas ...
C. L. R. Lima, A. P. Silva, S. Imhoff, H. V. Lima, T. P. Leão   +4 more
doaj   +1 more source