Results 41 to 50 of about 9,056 (295)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Compression stockings as an effective treatment for erythema nodosum: Case series

International Journal of Women's Dermatology, 2017
Erythema nodosum (EN) is a septal panniculitis that is characterized clinically by tender, erythematous, subcutaneous nodules that are predominately localized on the pretibial lower legs.
K.B. Golisch, BS, S.P. Gottesman, MD, R.J. Segal, MD   +2 more
doaj   +1 more source

Compression hosiery to avoid post-thrombotic syndrome (CHAPS) protocol for a randomised controlled trial (ISRCTN73041168)

BMJ Open, 2021
Introduction Up to 50% of patients develop post-thrombotic syndrome (PTS) after an above knee deep vein thrombosis (DVT). The aim of the study was to determine the effect of graduated compression stockings in preventing PTS after DVT.Methods and analysis
John Norrie, Rebecca Lawton, Nicky Cullum, Joseph Shalhoub, Beverley J Hunt, Robert Horne, Andrew Bradbury, David Epstein, Manjit Gohel, A H Davies, Ankur Thapar, Laura Burgess   +11 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Pressure mapping of medical compression bandages used for venous leg ulcer treatment [PDF]

, 2010
Chronic leg ulcers affect 1% of the adult population in the developed countries. The majority of leg ulcers are due to venous disease. The impact of venous ulcers on the quality of life is significant, and it costs the NHS £300 − 600m annually.
Al Khaburi, Jawad Ameen Jawad
core  

Graduated compression stockings in hip fractures

The Annals of The Royal College of Surgeons of England, 2012
INTRODUCTION Hip fractures are the most common cause of acute admissions to orthopaedics and in the UK approximately 70,000–75,000 hip fractures occur annually. Hip fractures carry a significant risk of developing a venous thromboembolism. The National Institute for Health and Clinical Excellence (NICE) estimated that the risk of developing a venous ...
Alsawadi, A, Loeffler, M
openaire   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Compression levels for the compression and calf placebo stockings.

, 2013
Compression pressures applied over a range of distending circumferences can be seen at each region of interest for the calf placebo (A) and compression stockings (B).
Anastasia Dikareva (337255), Carlo Menon (337256), Victoria Elizabeth Claydon (337257), Clare Louise Protheroe (337254)   +3 more
core   +1 more source

Comparison of 15–20 mmHg versus 20–30 mmHg Compression Stockings in Reducing Occupational Oedema in Standing and Seated Healthy Individuals

International Journal of Vascular Medicine, 2018
Background. Elastic compression stockings (ECS) are effective in preventing and reducing occupational edema (OE), but the optimal pressure according to the prevalent working position during the day is still controversial. Objective.
Cleusa Ema Quilici Belczak, José Maria Pereira de Godoy, Amélia Cristina Seidel, Sergio Belczak, Rubiana Neves Ramos, Roberto Augusto Caffaro   +5 more
doaj   +1 more source