Results 21 to 30 of about 2,392 (204)
Securing the ofloxacin–ornidazole combination in the Democratic Republic of the Congo
Orapuh JournalIntroduction Pharmaceutical stability in tropical regions is a critical public health concern, as extreme heat and humidity can compromise drug integrity before the expiry date.
Luc Shabani +4 more
doaj +1 more source
In silico prediction of post-translational modifications in therapeutic antibodies
mAbs, 2022 Monoclonal antibodies are susceptible to chemical and enzymatic modifications during manufacturing, storage, and shipping. Deamidation, isomerization, and oxidation can compromise the potency, efficacy, and safety of therapeutic antibodies.
Shabdita Vatsa
doaj +1 more source
RB loss sensitizes cells to replication-associated DNA damage after PARP inhibition by trapping
Life Science Alliance, 2023 After PARP inhibition by trapping, cells lacking the RB tumor suppressor experience persistent replication stress and genomic instability that compromise cell viability.
Luis Gregory Zamalloa +5 more
doaj +1 more source
Active electrochemical interfaces stabilized through self-organized potential oscillations
Electrochemistry Communications, 2020 Some electrochemical systems are known to have higher average efficiency when operated under an oscillatory regime. Given the compromise between activity and stability, the stability of electrochemical interfaces in a self-organized, oscillatory state ...
Jéssica A. Nogueira +3 more
doaj +1 more source
Compromises in Occupational Choice and Stability of Vocational Education and Training
, 2021 This study examines whether premature termination of vocational training is more likely when trainees had to make compromises between their realistic occupational aspiration and their occupation trained for in terms of gender type, prestige and occupational interests.
Ahrens, Lea +3 more
openaire +4 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko +5 more
wiley +1 more source
The Relaxation Properties of Myofibrils Are Compromised by Amino Acids that Stabilize α-Tropomyosin [PDF]
Biophysical Journal, 2017 We investigated the functional impact of α-tropomyosin (Tm) substituted with one (D137L) or two (D137L/G126R) stabilizing amino acid substitutions on the mechanical behavior of rabbit psoas skeletal myofibrils by replacing endogenous Tm and troponin (Tn) with recombinant Tm mutants and purified skeletal Tn.
SCELLINI, BEATRICE +6 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Graft‐versus‐host disease (GvHD) remains one of the most significant complications of hematopoietic stem cell transplantation (HSCT). Abatacept, a selective T‐cell costimulation modulator, is a relatively novel prophylactic agent, though pediatric data remain limited.
Matthijs D. Kruizinga +3 more
wiley +1 more source
Optimization and Stability of Heat Engines: The Role of Entropy Evolution
Entropy, 2018 Local stability of maximum power and maximum compromise (Omega) operation regimes dynamic evolution for a low-dissipation heat engine is analyzed. The thermodynamic behavior of trajectories to the stationary state, after perturbing the operation regime ...
Julian Gonzalez-Ayala +4 more
doaj +1 more source
When an Egg Is Not an Egg: Compromised Maternal mRNA Storage and Stabilization [PDF]
Biology of Reproduction, 2011 Commentary on Medvedev et al., “Absence of MSY2 in mouse oocytes perturbs oocyte growth and maturation, RNA stability, and the transcriptome.”
openaire +2 more sources