Results 31 to 40 of about 2,392 (204)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Failure Assessment of Embankment Dam Elements: Case Study of the Pirot Reservoir System

Applied Sciences, 2022
The paper presents a functionality investigation of the key dam elements based on finite element analysis. A detailed analysis of filtration processes, dam strength, and the surrounding rock mass was conducted.
Dragan Rakić, Milan Stojković, Damjan Ivetić, Miroslav Živković, Nikola Milivojević   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Compromised stability of DNA methylation and transposon immobilization in mosaic Arabidopsis epigenomes [PDF]

Genes & Development, 2009
Transgenerational epigenetic inheritance has been defined by the study of relatively few loci. We examined a population of recombinant inbred lines with epigenetically mosaic chromosomes consisting of wild-type and CG methylation-depleted segments (epiRILs).
Reinders, Jon, Wulff, Brande B. H., Mirouze, Marie, Marí-Ordóñez, Arturo, Dapp, Mélanie, Rozhon, Wilfried, Bucher, Etienne, Theiler, Gregory, Paszkowski, Jerzy   +8 more
openaire   +4 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Characterizing Compromise Stability of Games Using Larginal Vectors [PDF]

, 2011
The core cover of a TU-game is a superset of the core and equals the convex hull of its larginal vectors. A larginal vector corresponds to an order of the players and describes the efficient payoff vector giving the first players in the order their utopia demand as long as it is still possible to assign the remaining players at least their minimum ...
Platz, T.T., Hamers, H.J.M., Quant, M.
openaire   +4 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structural stability of symmetric bispecific antibodies: a case study showing potential compromise near linker regions

Scientific Reports
Over recent decades, bispecific antibodies (bsAbs) have garnered significant attention for their superior therapeutic efficacy compared to progenitor monoclonal antibodies, enabling innovative treatment strategies.
Nattha Ingavat, Yee Jiun Kok, Nuruljannah Dzulkiflie, Liew Jia Min, Wang Xinhui, Kia Ngee Low, Ka Pui But, Amihan Anajao, Loh Han Ping, Han Kee Ong, Farouq Bin Mahfut, Yuansheng Yang, Xuezhi Bi, Wei Zhang   +13 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The effect of career compromise on nurses’ turnover intention: the mediating role of job satisfaction

BMC Nursing
Aim We aimed to examine the relationships among nurses’ career compromise, job satisfaction, and turnover intention and the mediating role of job satisfaction in the relationship between career compromise and turnover intention.
Zhanghao Xie, Zhongqing Chen, Waner Wang, Jiangfeng Pu, Gege Li, Jiehao Zhuang, Xuanhao Fan, Ziyi Xiong, Hanxi Chen, Yuemei Liang, Peng Xu, Huigen Huang   +11 more
doaj   +1 more source