Results 51 to 60 of about 2,392 (204)

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Signatures of Conformational Stability and Oxidation Resistance in Proteomes of Pathogenic Bacteria

Cell Reports, 2014
Protein oxidation is known to compromise vital cellular functions. Therefore, invading pathogenic bacteria must resist damage inflicted by host defenses via reactive oxygen species.
Anita Vidovic, Fran Supek, Andrea Nikolic, Anita Krisko   +3 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Multi-Objective Genetic Algorithm for voltage stability enhancement using rescheduling and FACTS devices

Ain Shams Engineering Journal, 2014
This paper presents the application of Multi-Objective Genetic Algorithm to solve the Voltage Stability Constrained Optimal Power Flow (VSCOPF) problem.
J. Preetha Roselyn, D. Devaraj, Subhransu Sekhar Dash   +2 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Influence of varying oral pH conditions on the material stability of thermoplastic orthodontic aligners: an in vitro study

BMC Oral Health
Background Clear thermoplastic orthodontic aligners are widely used due to their aesthetic appeal and patient comfort; however, exposure to chemically diverse intraoral environments may compromise their physical, aesthetic, and chemical stability.
Dhruv Ahuja, Bhawna Negi, Anjana Goyal, Puneet Batra, Ashith MV, Kumar Rakshak Anand, Khushi Gupta, Bhoomi Pitanjali Singh, Areeba Parvez   +8 more
doaj   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

An Intuitionistic Fuzzy Multi-Criteria Approach for Prioritizing Failures That Cause Overproduction: A Case Study in Process Manufacturing

Axioms
Overproduction is one of the most significant wastes of Lean that can occur in any manufacturing company. Identifying and prioritizing failures that lead to overproduction are crucial tasks for operational managers and engineers.
Ranka Sudžum, Snežana Nestić, Nikola Komatina, Milija Kraišnik   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source