Results 61 to 70 of about 2,392 (204)

DYNAMIC DETERMINATION OF INFORMATION SYSTEM SECURITY PARAMETERS BASED ON ATTACK GRAPHS AND MARKOV MODELS UNDER CONDITIONS OF UNCERTAINTY

Scientific Journal of Astana IT University
The article presents an approach to the dynamic determination of information system security parameters under conditions of uncertainty and incomplete monitoring data.
Nazym Zhumangaliyeva, Lazat Kydyralina , Guljanat Esenbekova, Dmytro Prokopovych-Tkachenko, Mykola Mormul   +4 more
doaj   +1 more source

Does Crop Diversification Involve a Trade-Off Between Technical Efficiency and Income Stability for Rural Farmers? Evidence from Zambia

Agronomy, 2020
Crop diversification is a climate-smart agricultural technique which helps to improve resilience for farmers in the face of volatile weather due to climate change. Previous research on its effects on technical efficiency has shown mixed results.
Agness Mzyece, John N. Ng’ombe
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Hybrid External Fixation as A Comprehensive, Safe, and Effective Solution for Periarticular Tibial Fracture with Soft Tissue Compromise

Journal of Orthopaedic Case Reports
Introduction: High-energy trauma to the knee and ankle resulting in complex periarticular fractures of the tibia is usually difficult to treat using conventional plating methods owing to the association of poor soft-tissue conditions. The hybrid external
Vejaya Kumar, Srinivasan Balasubramanian, Saravanan Kasirajan   +2 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Comprehensive Analysis and Stabilization of a B2B HVDC System Connecting Two Extremely Weak Grids Considering the Impact of Power Feedforward Compensation

IEEE Open Journal of Power Electronics
Back-to-Back (B2B) HVDC systems can enhance cross-regional transmission capacity and overall power system stability. However, their use in interconnecting two extremely weak grids can compromise system stability.
Hassanien Ramadan A. Mohamed, Yasser Abdel-Rady I. Mohamed   +1 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Substitution of Nd with other rare earth elements in melt spun Nd2Fe14B magnets

AIP Advances, 2016
This is a contemporary study of rapidly quenched Nd1.6X0.4Fe14B magnetic materials (where X= Nd, Y, Ce, La, Pr, Gd and Ho). A 20% substitution of the Nd component from Nd2Fe14B can bring about some commercial advantage.
D. N. Brown, D. Lau, Z. Chen
doaj   +1 more source