Results 81 to 90 of about 128,864 (318)

Preexisting risk-avoidance and enhanced alcohol relief are driven by imbalance of the striatal dopamine receptors in mice

Nature Communications
Alcohol use disorder (AUD) is frequently comorbid with anxiety disorders, yet whether alcohol abuse precedes or follows the expression of anxiety remains unclear.
Miriam E. Bocarsly, Marlisa J. Shaw, Emilya Ventriglia, Lucy G. Anderson, Hannah C. Goldbach, Catherine E. Teresi, Marilyn Bravo, Roland Bock, Patrick Hong, Han Bin Kwon, Imran M. Khawaja, Rishi Raman, Erin M. Murray, Jordi Bonaventura, Dennis A. Burke, Michael Michaelides, Veronica A. Alvarez   +16 more
doaj   +1 more source

The effects of comorbid Tourette symptoms on distress caused by compulsive-like behavior in very young children: a cross-sectional study

Child and Adolescent Psychiatry and Mental Health, 2019
Background Many children 4 to 6 years old exhibit compulsive-like behavior, often with comorbid Tourette symptoms, making this age group critical for investigating the effects of having comorbid Tourette symptoms with compulsive-like behavior.
Ryunosuke Goto, Miyuki Fujio, Natsumi Matsuda, Mayu Fujiwara, Marina Nobuyoshi, Maiko Nonaka, Toshiaki Kono, Masaki Kojima, Norbert Skokauskas, Yukiko Kano   +9 more
doaj   +1 more source

The mediating roles of disgust sensitivity and danger expectancy in relation to hand washing behaviour

, 2010
Copyright © 2010 British Association for Behavioural and Cognitive PsychotherapiesBackground: Recent interest in the role of vulnerability factors in obsessional washing has suggested that disgust sensitivity, danger expectancy and health anxiety may be ...
Nottingham, K, Katy Friend, Thorpe, SJ, Friend, K, Julie Barnett, Kate Nottingham, Barnett, J, Susan J. Thorpe   +7 more
core   +1 more source

CYP2C19 Genotype is Associated with Citalopram Treatment Outcomes in a Real‐World Setting

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2C19 metabolizes various selective serotonin reuptake inhibitors (SSRIs) and genetic CYP2C19 variants are associated with SSRI tolerability and response. Yet, whether CYP2C19 variability also impacts citalopram response remained unclear. We here evaluated associations between CYP2C19 genotypes and citalopram prescription data of 11,079 patients from
Yoomi Park, Yitian Zhou, Volker M. Lauschke   +2 more
wiley   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Early life adversity increases striatal dopamine D1 receptor density and promotes social alcohol drinking in mice, especially males

Translational Psychiatry
The brain’s reward-processing circuitry remains sensitive to experience throughout early life and into adulthood, allowing individuals to adapt to their unique environments.
Lucy G. Anderson, Anna E. Tischer, Roland Bock, Michael Michaelides, Veronica A. Alvarez   +4 more
doaj   +1 more source

Compulsive Buying Behaviour in Estonian Market

Economics and Business, 2015
This research is conducted about compulsive buying behaviour in Estonia. The current research purpose is to find out how many people are affected by compulsive buying behaviour in Estonia and what factors are influencing this phenomenon.
Raudsepp Marju, Parts Oliver
doaj   +1 more source

Measuring harm avoidance, incompleteness, and disgust in youth with obsessive-compulsive disorder and anxiety disorders

, 2019
Alongside harm avoidance, incompleteness and disgust have been proposed as important emotion-related motivators underlying the symptoms of obsessive-compulsive disorder (OCD).
Perrin, Sean,, Lund University., Cervin, Matti,   +2 more
core   +1 more source

From Custom to Court: The Evolution of Mediation in European Legal Systems

Conflict Resolution Quarterly, EarlyView.
ABSTRACT This article traces how European mediation has repeatedly rebalanced three variables—(1) the source of mediator authority, (2) the degree of institutionalization, and (3) the operative meaning of voluntariness—from antiquity to the present. Using three periods—Proto‐Mediation (c. 500 BCE–c. 1750), Classical Mediation (c.
Viktoriia Hamaiunova
wiley   +1 more source

Off-label higher doses of serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder: Safety and tolerability

Comprehensive Psychiatry
Objective: To examine the long-term safety and tolerability of off-label high-dose serotonin reuptake inhibitors (OLHD-SRIs) in the treatment of obsessive-compulsive disorder (OCD).
Daniel Minkin Levy, Oded Ben Arush, Lior Carmi, Alzbeta Juven Wetzler, Joseph Zohar   +4 more
doaj   +1 more source