Results 11 to 20 of about 6,390,061 (301)

Hyperactivity of indirect pathway-projecting spiny projection neurons promotes compulsive behavior [PDF]

Nature Communications
Compulsive behaviors are a hallmark symptom of obsessive compulsive disorder (OCD). Striatal hyperactivity has been linked to compulsive behavior generation in correlative studies in humans and causal studies in rodents.
Sean C. Piantadosi, Elizabeth E. Manning, Brittany L. Chamberlain, James Hyde, Zoe LaPalombara, Nicholas M. Bannon, Jamie L. Pierson, Vijay M. K Namboodiri, Susanne E. Ahmari   +8 more
doaj   +3 more sources

Defining Compulsive Behavior. [PDF]

Neuropsychol Rev, 2019
Compulsive tendencies are a central feature of problematic human behavior and thereby are of great interest to the scientific and clinical community. However, no consensus exists about the precise meaning of 'compulsivity,' creating confusion in the field and hampering comparison across psychiatric disorders.
Luigjes J, Lorenzetti V, de Haan S, Youssef GJ, Murawski C, Sjoerds Z, van den Brink W, Denys D, Fontenelle LF, Yücel M.   +9 more
europepmc   +12 more sources

Transdiagnostic phenotypes of compulsive behavior and associations with psychological, cognitive, and neurobiological affective processing [PDF]

Translational Psychiatry, 2022
Compulsivity is a poorly understood transdiagnostic construct thought to underlie multiple disorders, including obsessive-compulsive disorder, addictions, and binge eating.
Lauren Den Ouden, Chao Suo, Lucy Albertella, Lisa-Marie Greenwood, Rico S. C. Lee, Leonardo F. Fontenelle, Linden Parkes, Jeggan Tiego, Samuel R. Chamberlain, Karyn Richardson, Rebecca Segrave, Murat Yücel   +11 more
doaj   +3 more sources

Disruption of prepulse inhibition is associated with compulsive behavior severity and nucleus accumbens dopamine receptor changes in Sapap3 knockout mice [PDF]

Scientific Reports, 2021
Obsessive compulsive disorder (OCD) is associated with disruption of sensorimotor gating, which may contribute to difficulties inhibiting intrusive thoughts and compulsive rituals.
Elizabeth E. Manning, Abigail Y. Wang, Linda M. Saikali, Anna S. Winner, Susanne E. Ahmari   +4 more
doaj   +3 more sources

Neuroscience of Compulsive Eating Behavior [PDF]

Frontiers in Neuroscience, 2017
A systematic characterization of compulsivity in pathological forms of eating has been proposed in the context of three functional domains: (1) habitual overeating; (2) overeating to relieve a negative emotional state; and (3) overeating despite aversive
Catherine F. Moore, Catherine F. Moore, Valentina Sabino, George F. Koob, Pietro Cottone   +4 more
doaj   +4 more sources

Exploring the relationship between materialism, consumer ethnocentrism, and compulsive buying [PDF]

Frontiers in Psychology
Materialistic values, consumer ethnocentrism, and compulsive buying represent three significant concepts in the field of consumer behavior. Theoretical models suggest that materialism may contribute to impulsive and compulsive purchasing behavior, while ...
Róbert Štefko, Martin Rigelský, Ivana Ondrijová, Lenka Kráľová   +3 more
doaj   +2 more sources

High-frequency neuromodulation improves obsessive-compulsive behavior. [PDF]

Nat Med, 2021
Grover S, Nguyen JA, Viswanathan V, Reinhart RMG.   +3 more
europepmc   +2 more sources

Ketamine increases activity of a fronto-striatal projection that regulates compulsive behavior in SAPAP3 knockout mice. [PDF]

Nat Commun, 2021
Obsessive-Compulsive Disorder (OCD), characterized by intrusive thoughts (obsessions) and repetitive behaviors (compulsions), is associated with dysfunction in fronto-striatal circuits.
Davis GL, Minerva AR, Lario A, Simmler LD, Rodriguez CI, Gunaydin LA.   +5 more
europepmc   +2 more sources

Effect of Experimental Manipulation of the Orbitofrontal Cortex on Short-Term Markers of Compulsive Behavior: A Theta Burst Stimulation Study. [PDF]

Am J Psychiatry, 2021
OBJECTIVE Compulsive behaviors are a core feature of obsessive-compulsive spectrum disorders but appear across a broad spectrum of psychological conditions.
Price RB, Gillan CM, Hanlon C, Ferrarelli F, Kim T, Karim HT, Renard M, Kaskie R, Degutis M, Wears A, Vienneau EP, Peterchev AV, Brown V, Siegle GJ, Wallace ML, Ahmari SE.   +15 more
europepmc   +2 more sources

Visuospatial working memory capacity moderates the relationship between anxiety and OCD related checking behaviors

Frontiers in Psychiatry, 2023
BackgroundCompulsive checking behavior is the most prevalent compulsive behavior in patients with obsessive-compulsive disorder (OCD). While some studies have shown that anxiety and executive function influence compulsive checking behavior, the ...
Pengchong Wang, Pengchong Wang, Zijun Yan, Zijun Yan, Tao Chen, Tao Chen, Wenwen Cao, Wenwen Cao, Xiangyun Yang, Xiangyun Yang, Fanqiang Meng, Fanqiang Meng, Yuqing Liu, Yuqing Liu, Zhanjiang Li, Zhanjiang Li   +15 more
doaj   +1 more source