Results 81 to 90 of about 58,348 (262)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Unemployment and Subsequent Wages: Does Gender Matter? [PDF]
Are there any differences in how men and women fare from unemployment in terms of the wages they receive on a new job? This paper addresses that question using the 1991 wave of the Level of Living Survey.
Wiklund, Fredrik
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Revista de Paz y Conflictos, 2017 This paper offers a basic model of some of the main intersecting causes of the early abandonment and school failure of the Gitano or Spanish Romani adolescents.
Ivan Parra Toro +2 more
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Emissions by aerial routes from protected crop systems (greenhouses and crops grown under cover) : a position paper [PDF]
, 2009 This report describes the processes that may lead to emission of Plant Protection Products (PPP) from protected cultivation, through aerial routes. The introduction gives the background for this work and the limitations, outlining in particular why ...
Stanghellini, C.
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Regulating crime prevention design into consumer products: learning the lessons from electronic vehicle immobilisation [PDF]
Foreword Despite significant reductions in recent years, acquisitive property crime remains the single largest crime category, with over 700,000 offences recorded annually by police in Australia.
Rick Brown
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Long term effects of a mandatory multistage program:the new deal for young people in the UK [PDF]
, 2005 The New Deal For Young People is the major welfare-to-work program in the UK. It is amandatory multistage policy targeted at the 18-24 year old unemployed. This paper investi-gates the effectiveness of the program in terms of enhancing the (re)employment
De Giorgi, G
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source