Eradication of scrapie with selective breeding: are we nearly there? [PDF]
, 2010 Background: Following EU decision 2003/100/EC Member States have recently implemented sheep breeding programmes to reduce the prevalence of sheep with TSE susceptible prion genotypes.
Melchior, M.B. +5 more
core +2 more sources
Drivers’ Knowledge, Attitude and Practices Towards Traffic Rules and Regulations
Journal of Road SafetyResearch frequently reports that the majority of crashes (up to 80%), are the fault of drivers. Further, the WHO reports that most fatal crashes occur in low- and middle-income countries (LMIC).
Sheer Abbas +3 more
doaj +1 more source
The Bellagio Global Dialogues on Intellectual Property [PDF]
, 2006 Reviews Rockefeller's conference series on intellectual property and its efforts to promote policies and institutional capacities that better serve the poor, with a focus on food security and public health.
Joe Karaganis
core
The Intellectual Property Provisions of the United States-Jordan Free Trade Agreement: Template or Not Template [PDF]
, 2006 The objective of this article is to examine the implications of the intellectual property provisions in the US–Jordan Free Trade Agreement (US–JO FTA) and whether they serve as a template for other Arab countries who will be concluding free ...
Malkawi, Bashar H.
core +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Intellectual Property Management Strategies to Accelerate the Development and Access of Vaccines and Diagnostics: Case Studies on Pandemic Influenza, Malaria and SARS [PDF]
, 2006 Achieving global access to vaccines, diagnostics, and pharmaceuticals remains a challenge. Throughout the developing world, intellectual property (IP) constraints complicate access to critically essential medical technologies and products.
Eiss, Robert +3 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
The Amended Canadian Patent Act: General Amendments and Pharmaceutical Patents Compulsory Licensing Provisions [PDF]
, 1987 On November 19, 1987, the Canadian Senate gave final approval to a number of far-reaching and controversial amendments to the Canadian Patent Act ( Amending Act ).
Chromecek, Milan
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source