Results 101 to 110 of about 91,439 (301)

Проблемні питання безпеки дорожнього руху в Україні (повідомлення 2) = Topical issues of road-traffic safety in Ukraine (report 2)

open access: yesJournal of Education, Health and Sport, 2015
Lebedeva T. L. Проблемні питання безпеки дорожнього руху в Україні (повідомлення 2) = Topical issues of road-traffic safety in Ukraine (report 2). Journal of Education, Health and Sport. 2015;5(7):542-552. ISSN 2391-8306. DOI 10.5281/zenodo.28044 http:/
T. L. Lebedeva
doaj   +2 more sources

Interests Analysis on Compulsory License

open access: yesBeijing Law Review, 2016
In this paper I turn to different conceptions of interest. There are several theories in the field of political philosophy about what interest is and therefore several conceptions of interest exist. Three pairs of interest are clarified: interest as welfare and interest as resource, reflective interest and volitional interest, public interest and ...
openaire   +2 more sources

An Overview of Progress in the International Regulation of the Pharmaceutical Industry [PDF]

open access: yes, 2002
[Excerpt] “The pharmaceutical industry, a significant source of healthcare throughout the world, has several features that distinguish it from the rest of the health industry.
Burakoff, Aaron, Harvard University   +1 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

The Amended Canadian Patent Act: General Amendments and Pharmaceutical Patents Compulsory Licensing Provisions [PDF]

open access: yes, 1987
On November 19, 1987, the Canadian Senate gave final approval to a number of far-reaching and controversial amendments to the Canadian Patent Act ( Amending Act ).
Chromecek, Milan
core   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Investigating the current situation of chemical pesticides trade in Tripoli region and its suburbs in Libya

open access: yesJournal of Oasis Agriculture and Sustainable Development
This study was conducted within the framework of a research program at the Agricultural Research Center for Sustainable Development during the 2021-2022 agricultural season through field visits to pesticide marketing and storage sites in Tripoli and its
Osama Milud Sleik   +2 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

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