Results 31 to 40 of about 4,684 (246)
Регионология, 2023 Introduction. Import substitution is one of the key tasks of Russian politics and the economy of recent decades, which determines the relevance of studying this concept in other regions of the world to create the prerequisites for its most effective ...
Irina A. Emelkina, Olga N. Fomina
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Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
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SCRIPTed: A Journal of Law, Technology & Society, 2010 In keeping with the relatively new waiver of the requirement of domestic production under Article 31(f) of TRIPS, the Indian Patents Act 1970 was amended allowing for compulsory license in certain exceptional circumstances.
Swarup Kumar
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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從TRIPS 協定與公眾健康爭議論專利強制授權之功能與侷限 Functions and Restraints of Compulsory Licensing: Perspective from TRIPS Agreement and Public Health [PDF]
Kējì Fǎxué Pínglùn, 2004 對於專利強制授權（compulsory licensing）制度之實際功能，以往研究文獻大致有兩種看法，其一是認為強制授權制度雖被巴黎公約與TRIPS 協定所承認，並為世界各國普遍採行，但是強制授權之實際案例在各國均甚罕見，此一制度的實際功能如何，值得懷疑。其二則認為各國強制授權實際案例雖不甚多，但是強制授權制度之存在本身，即已提供國內廠商進行授權談判時之有力籌碼，其功能不可忽視。這兩種看法雖然各有所本，但是都未能提出可資驗證的直接論據。而隨著致命的愛滋病在開發中國家迅速蔓延，以及911 ...
王立達 Richard Li-Dar Wang
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
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Compulsory patent licensing and local drug manufacturing capacity in Africa
Bulletin of the World Health Organization, 2014 Africa has the highest disease burden in the world and continues to depend on pharmaceutical imports to meet public health needs. As Asian manufacturers of generic medicines begin to operate under a more protectionist intellectual property regime, their ...
Olasupo Ayodeji Owoeye
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
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Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
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