Results 51 to 60 of about 423,577 (305)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Compulsory patent licensing and local drug manufacturing capacity in Africa
Bulletin of the World Health Organization, 2014 Africa has the highest disease burden in the world and continues to depend on pharmaceutical imports to meet public health needs. As Asian manufacturers of generic medicines begin to operate under a more protectionist intellectual property regime, their ...
Olasupo Ayodeji Owoeye
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
從TRIPS 協定與公眾健康爭議論專利強制授權之功能與侷限 Functions and Restraints of Compulsory Licensing: Perspective from TRIPS Agreement and Public Health [PDF]
Kējì Fǎxué Pínglùn, 2004 對於專利強制授權（compulsory licensing）制度之實際功能，以往研究文獻大致有兩種看法，其一是認為強制授權制度雖被巴黎公約與TRIPS 協定所承認，並為世界各國普遍採行，但是強制授權之實際案例在各國均甚罕見，此一制度的實際功能如何，值得懷疑。其二則認為各國強制授權實際案例雖不甚多，但是強制授權制度之存在本身，即已提供國內廠商進行授權談判時之有力籌碼，其功能不可忽視。這兩種看法雖然各有所本，但是都未能提出可資驗證的直接論據。而隨著致命的愛滋病在開發中國家迅速蔓延，以及911 ...
王立達 Richard Li-Dar Wang
doaj
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
TRIPS, eBay, and Denials of Injunctive Relief: Is Article 31 Compliance Everything? [PDF]
, 2009 In eBay, Inc. v. MercExchange, L.L.C., the Supreme Court held that decisions to grant injunctive relief must accord with the traditional principles of equity, thereby invalidating the practice of generally granting permanent injunctions to patentees upon
Mace, Andrew C.
core +2 more sources
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
The African Journal of Information and Communication, 2015 Pharmaceutical firms' use of strategic patenting to influence the markets within which their patented inventions sit is legally questionable. Such patenting entails filing patents with the intention of blocking potential competitors from innovating and ...
Vuyisile Hobololo
doaj +3 more sources
BMC Public Health, 2021 Background It is now 25 years since the adoption of the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS) and the same concerns raised during its negotiations such as high prices of medicines, market exclusivity and delayed ...
Marion Motari +6 more
doaj +1 more source