Results 141 to 150 of about 3,508,326 (346)

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Consciousness qua Mortal Computation [PDF]

arXiv
Computational functionalism posits that consciousness is a computation. Here we show, perhaps surprisingly, that it cannot be a Turing computation. Rather, computational functionalism implies that consciousness is a novel type of computation that has recently been proposed by Geoffrey Hinton, called mortal computation.
arxiv  

Finite Computational Structures and Implementations [PDF]

arXiv, 2016
What is computable with limited resources? How can we verify the correctness of computations? How to measure computational power with precision? Despite the immense scientific and engineering progress in computing, we still have only partial answers to these questions.
arxiv  

On logarithmic-graphic computation. [II.] [PDF]

, 1916
Václav Obešlo
openalex   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

On a method of computation of a triangle with given three sides or with given two sides and included angle [PDF]

, 1879
Augustin Pánek
openalex   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

La informática en el mundo actual: la educación y en la medicina Computing in the current times: Education & Medicine

Humanidades Médicas, 2008
Este trabajo tiene como objetivo principal analizar el Impacto Social de la nueva Revolución Científico Técnica en el panorama del mundo actual y principalmente en la esfera de la educación y la medicina.
Cordovés Macías Mayra Luciana, Raúl Urquiaga Rodríguez   +1 more
doaj  

On logarithmic-graphic computation. [I.] [PDF]

, 1916
Václav Obešlo
openalex   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source