Results 111 to 120 of about 95,049 (308)

Making GenAI valuable: Benchmarks, singularities, and the enrichment economy

Big Data & Society
As investment in Generative AI (GenAI) has reached tens and hundreds of billions, anxieties about an ‘AI bubble’ have been on the rise. This article offers an alternative perspective on how GenAI is made valuable.
Claudia Aradau, Tobias Blanke
doaj   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

A study of valence & argument integration in Chinese verb-resultative complement

, 2023
30th Pacific Asia Conference on Language, Information and Computation, Oct. 2016, Seoul, South Korea202304 bcwwVersion of RecordOthersThis paper is supported by National Key Basic Research Program of China No.2014CB340504 and Major Project of Humanities &
Li, A
core  

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Computational description of the Kazakh language [PDF]

Proceedings of the 5th conference on Computational linguistics -, 1973
Dzhubanov, Askar, Khasanov, Bakhitdzhan
openaire   +2 more sources

Logics for Dynamics of Information and Preferences: Seminar’s yearbook 2008 [PDF]

, 2009
This collection contains selected papers that have been presented and discussed during the year 2008 at the seminar "Logics for Dynamics of Information and Preferences", a regular event at the Institute for Logic, Language and Computation (ILLC) of the ...
Kurzen, L., Velázquez-Quesada, F.R.
core   +1 more source

Arithmetical definability over finite structures

, 2002
Arithmetical definability has been extensively studied over the natural numbers. In this paper, we take up the study of arithmetical definability over finite structures, motivated by the correspondence between uniform ¢¡¤ £ and ¥§¦©¨ ¤
Lee, T.J., Troy Lee
core   +1 more source