Results 71 to 80 of about 1,973,231 (200)

HER2 is not a cancer subtype but rather a pan-cancer event and is highly enriched in AR-driven breast tumors

Breast Cancer Research, 2018
Background Approximately one in five breast cancers are driven by amplification and overexpression of the human epidermal growth factor receptor 2 (HER2) receptor kinase, and HER2-enriched (HER2E) is one of four major transcriptional subtypes of breast ...
Anneleen Daemen, Gerard Manning
doaj   +1 more source

Preface to Introduction to Protein Structural Bioinformatics [PDF]

, 2018
While many good textbooks are available on Protein Structure, Molecular Simulations, Thermodynamics and Bioinformatics methods in general, there is no good introductory level book for the field of Structural Bioinformatics.
Abeln, Sanne, Feenstra, K. Anton, Feenstra, K. Anton; id_orcid, Abeln, Sanne; id_orcid   +3 more
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Computational and Mathematical Modelling of the EGF Receptor System [PDF]

, 2008
This chapter gives an overview of computational and mathematical modelling of the EGF receptor system. It begins with a survey of motivations for producing such models, then describes the main approaches that are taken to carrying out such modelling, viz.
Emmet McIntyre, McIntyre, Emmet, Colin G. Johnson, William Gullick, Johnson, Colin G., Gullick, William J.   +5 more
core   +1 more source

Systematic analysis of the intersection of disease mutations with protein modifications

BMC Medical Genomics, 2019
Background Perturbed posttranslational modification (PTM) landscapes commonly cause pathological phenotypes. The Cancer Genome Atlas (TCGA) project profiles thousands of tumors allowing the identification of spontaneous cancer-driving mutations, while ...
Claire M. Simpson, Bin Zhang, Peter V. Hornbeck, Florian Gnad   +3 more
doaj   +1 more source

Transposable elements contribute to cell and species-specific chromatin looping and gene regulation in mammalian genomes

Nature Communications, 2020
A fraction of mammalian CTCF binding sites fall within transposable elements (TEs) but their contribution to the evolution of 3D chromatin structure is unknown.
Adam G. Diehl, Ningxin Ouyang, Alan P. Boyle   +2 more
doaj   +1 more source

Selected Works in Bioinformatics [PDF]

, 2011
This book consists of nine chapters covering a variety of bioinformatics subjects, ranging from database resources for protein allergens, unravelling genetic determinants of complex disorders, characterization and prediction of regulatory motifs ...

core   +1 more source

Module control of network analysis in psychopathology

iScience
Summary: The network approach to characterizing psychopathology departs from traditional latent categorical and dimensional approaches. Causal interplay among symptoms contributed to dynamic psychopathology system.
Chunyu Pan, Quan Zhang, Yue Zhu, Shengzhou Kong, Juan Liu, Changsheng Zhang, Fei Wang, Xizhe Zhang   +7 more
doaj   +1 more source

Identifying and mitigating batch effects in whole genome sequencing data

BMC Bioinformatics, 2017
Background Large sample sets of whole genome sequencing with deep coverage are being generated, however assembling datasets from different sources inevitably introduces batch effects.
Jennifer A. Tom, Jens Reeder, William F. Forrest, Robert R. Graham, Julie Hunkapiller, Timothy W. Behrens, Tushar R. Bhangale   +6 more
doaj   +1 more source

Guest Editorial for the ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics

, 2019
It is our great pleasure to present this special issue of the IEEE/ACM Transactions on Computational Biology and Bioinformatics. The special issue includes six papers, which were invited from the ACM Conference on Bioinformatics, Computational Biology ...
Pozzi, Giuseppe, Kahveci, Tamer, Shehu, Amarda   +2 more
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Assessment of circulating proteins in thyroid cancer: Proteome-wide Mendelian randomization and colocalization analysis

iScience
Summary: The causality between circulating proteins and thyroid cancer (TC) remains unclear. We employed five large-scale circulating proteomic genome-wide association studies (GWASs) with up to 100,000 participants and a TC meta-GWAS (nCase = 3,418 ...
Qinghua Fan, Shifeng Wen, Yi Zhang, Xiuming Feng, Wanting Zheng, Xiaolin Liang, Yutong Lin, Shimei Zhao, Kaisheng Xie, Hancheng Jiang, Haifeng Tang, Xiangtai Zeng, You Guo, Fei Wang, Xiaobo Yang   +14 more
doaj   +1 more source