Results 131 to 140 of about 17,712,238 (346)
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Computational fluid dynamics: Transition to design applications [PDF]
The development of aerospace vehicles, over the years, was an evolutionary process in which engineering progress in the aerospace community was based, generally, on prior experience and data bases obtained through wind tunnel and flight testing. Advances
Bhateley, I. C. +2 more
core +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Principles of Protein Stability and Their Application in Computational Design.
Annual Review of Biochemistry, 2018 Proteins are increasingly used in basic and applied biomedical research. Many proteins, however, are only marginally stable and can be expressed in limited amounts, thus hampering research and applications.
A. Goldenzweig, S. Fleishman
semanticscholar +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Algorithms, 2019 Most of the architectural design problems are basically real-parameter optimization problems. So, any type of evolutionary and swarm algorithms can be used in this field.
Cemre Cubukcuoglu +3 more
doaj +1 more source
Computational Design of Thermally Activated Delayed Fluorescence Materials: The Challenges Ahead.
Journal of Physical Chemistry Letters, 2018 Thermally activated delayed fluorescence (TADF) offers promise for all-organic light-emitting diodes with quantum efficiencies competing with those of transition-metal-based phosphorescent devices.
Y. Olivier +5 more
semanticscholar +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Calibration of a Low-Cost Methane Sensor Using Machine Learning
SensorsIn order to combat greenhouse gas emissions, the sources of these emissions must be understood. Environmental monitoring using low-cost wireless devices is one method of measuring emissions in crucial but remote settings, such as peatlands.
Hazel Louise Mitchell +2 more
doaj +1 more source
Computer-aided molecular design
Computer-Aided Design, 1985 Abstract Computer-aided molecular design has come of age. In the pharmaceutical and fine chemical industries computer graphics techniques allied to theoretical calculations are proving successful in suggesting to synthetic chemists molecules which will merit synthesis in terms of desired specific properties.
openaire +2 more sources