Results 151 to 160 of about 769,896 (315)
Confronting the Challenges of Computational Design Instruction [PDF]
, 2014 Many architects understand that learning to program can be a challenge, but assume that time and practice are the only barriers to performing well enough at it.
N. Senske
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Computational design of metalloproteases
Abstract Although significant progress has been made in creating de novo metalloenzymes that hydrolyze activated esters 1,2 , the energetically demanding cleavage of amide bonds has remained a major challenge for enzyme design: amide bonds are ...
Anqi Chen +17 more
openaire +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem +17 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang +8 more
wiley +1 more source
Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source
The use of computational fluid dynamics in the optimisation of marine current turbines [PDF]
, 2007 The use of Computational Fluid Dynamics (CFD) in research and development in industry has become much more commonplace. Technological advances have improved the accuracy of codes although this is at the expense of computational power.
Nicholls-Lee, R.F., Turnock, S.R.
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A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source
Evidence of assessing computational thinking [PDF]
, 2014 Computational thinking is at the heart of the new English national curriculum for computing. There is a range of academic and pedagogic interpretations of the concept of computational thinking, a lack of understanding of the concepts and a close ...
Woollard, John +2 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao +6 more
wiley +1 more source
A Methodology for Computational Architectural Design Based on Biological Principles [PDF]
, 2013 Biomimicry, where nature is emulated as a basis for design, is a growing area of research in the fields of architecture and engineering. The widespread and practical application of biomimicry as a design approach remains however largely unrealized.
Hanafi, M. (author) +8 more
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