Results 31 to 40 of about 1,304,365 (227)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The body as a reservoir: locomotion and sensing with linear feedback [PDF]

, 2011
It is known that mass-spring nets have computational power and can be trained to reproduce oscillating patterns. In this work, we extend this idea to locomotion and sensing. We simulate systems made out of bars and springs and show that stable gaits can
Caluwaerts, Ken, Schrauwen, Benjamin
core  

Discovering Communication [PDF]

, 2006
What kind of motivation drives child language development? This article presents a computational model and a robotic experiment to articulate the hypothesis that children discover communication as a result of exploring and playing with their environment.
Oudeyer, Dr. P-Y.
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Expansion-maximization-compression algorithm with spherical harmonics for single particle imaging with X-ray lasers

, 2016
In 3D single particle imaging with X-ray free-electron lasers, particle orientation is not recorded during measurement but is instead recovered as a necessary step in the reconstruction of a 3D image from the diffraction data.
Bihan, Nicolas Le, Flamant, Julien, Manton, Jonathan H., Martin, Andrew V.   +3 more
core   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Experimental quantum tossing of a single coin

, 2008
The cryptographic protocol of coin tossing consists of two parties, Alice and Bob, that do not trust each other, but want to generate a random bit. If the parties use a classical communication channel and have unlimited computational resources, one of ...
A T Nguyen, Ambainis A, Bennett C H, Buhrman H, Goldwasser S, Gutoski G, J Frison, Jain R, K Phan Huy, Kitaev A Y, Legre M, Mayers D, Mayers D Salvail L Chiba-Kohno Y, Mochon C, S Massar   +14 more
core   +2 more sources

Research and Education in Computational Science and Engineering [PDF]

, 2016
Over the past two decades the field of computational science and engineering (CSE) has penetrated both basic and applied research in academia, industry, and laboratories to advance discovery, optimize systems, support decision-makers, and educate the ...
Biros, George, Bungartz, Hans, Corones, James, Cramer, Evin, Crowley, James, De Sterck, Hans, Ghattas, Omar, Gunzburger, Max, Hanke, Michael, Harrison, Robert, Heroux, Michael, Hesthaven, Jan, Jimack, Peter, Johnson, Chris, Jordan, Kirk E., Keyes, David E., Krause, Rolf, Kumar, Vipin, Mayer, Stefan, McInnes, Lois Curfman, Meza, Juan, Mørken, Knut Martin, Oden, J. Tinsley, Petzold, Linda, Raghavan, Padma, Rüde, Ulrich, Shontz, Suzanne M., Trefethen, Anne, Turner, Peter, Voevodin, Vladimir, Willcox, Karen, Wohlmuth, Barbara, Woodward, Carol S.   +32 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source