Results 31 to 40 of about 72,919 (260)
Bayesian calibration of irradiated graphite property models under high temperatures
npj Materials DegradationGraphite under high temperatures and irradiation is central to advanced reactors. We develop a Bayesian calibration framework for graphite property models that explicitly represents model-data mismatch via a Gaussian-process discrepancy.
Somayajulu L. N. Dhulipala +3 more
doaj +1 more source
Simulation of contact forces and contact characteristics during meshing of elastic beveloid gears
Computer Assisted Methods in Engineering and Science, 2017 Beveloid gears, also known as conical involute gears with very complex tooth shapes, gain more and more importance in industrial practice due to their ability to realize gear stages with crossed axes.
Trong Phu Do +2 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Modeling of skin tissue heating using the generalized dual phase-lag equation
Archives of Mechanics, 2015 This paper concerns the numerical modeling of skin tissue heating. To describe the analyzed process the system of three generalized dual phase-lag equations corresponding to the successive layers of the skin: epidermis, dermis and sub-cutaneous region is
E. Majchrzak +2 more
doaj +1 more source
Conference on Lasers and Electro-Optics, 1984 The physical limitations, due to quantum mechanics, on the functioning of computers are analyzed.
openaire +4 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEniCS mechanics: A package for continuum mechanics simulations
SoftwareX, 2019 FEniCS Mechanics is a Python package to facilitate computational mechanics simulations. The Python library dolfin, from the FEniCS Project, is used to formulate and numerically solve the problem in variational form.
Miguel A. Rodriguez +2 more
doaj +1 more source
Computational Mechanisms and Models of Computation [PDF]
Philosophia Scientiae, 2014 Dans la plupart des descriptions de la réalisation des processus computationnels par des mécanismes physiques, on présuppose une correspondance terme à terme entre les états causalement actifs des processus physiques et les états de la computation. Cependant, soit de telles propositions stipulent qu’un seul modèle de computation est implémenté, soit ...
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source