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The Origins of Computational Mechanics: A Brief Intellectual History and Several Clarifications [PDF]
, 2017 The principle goal of computational mechanics is to define pattern and structure so that the organization of complex systems can be detected and quantified.
Crutchfield, James P.
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Simulation of contact forces and contact characteristics during meshing of elastic beveloid gears
Computer Assisted Methods in Engineering and Science, 2017 Beveloid gears, also known as conical involute gears with very complex tooth shapes, gain more and more importance in industrial practice due to their ability to realize gear stages with crossed axes.
Trong Phu Do +2 more
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Stochastic Eulerian Lagrangian Methods for Fluid-Structure Interactions with Thermal Fluctuations
, 2010 We present approaches for the study of fluid-structure interactions subject to thermal fluctuations. A mixed mechanical description is utilized combining Eulerian and Lagrangian reference frames.
Alberts +63 more
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Modeling of skin tissue heating using the generalized dual phase-lag equation
Archives of Mechanics, 2015 This paper concerns the numerical modeling of skin tissue heating. To describe the analyzed process the system of three generalized dual phase-lag equations corresponding to the successive layers of the skin: epidermis, dermis and sub-cutaneous region is
E. Majchrzak +2 more
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
, 1993 The Computational Mechanics thrust area sponsors research into the underlying solid, structural and fluid mechanics and heat transfer necessary for the development of state-of-the-art general purpose computational software. The scale of computational capability spans office workstations, departmental computer servers, and Cray-class supercomputers. The
openaire +4 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Documenting research software in engineering science
Scientific Reports, 2022 The reuse of research software needs good documentation, however, the documentation in particular is often criticized. Especially in non-IT specific disciplines, the lack of documentation is attributed to the lack of training, the lack of time or missing
Sibylle Hermann, Jörg Fehr
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