Results 151 to 160 of about 297,450 (276)

Building on models-a perspective for computational neuroscience. [PDF]

Cereb Cortex
Plesser HE, Davison AP, Diesmann M, Fukai T, Gemmeke T, Gleeson P, Knight JC, Nowotny T, René A, Rhodes O, Roque AC, Senk J, Schwalger T, Stadtmann T, Tiddia G, van Albada SJ.   +15 more
europepmc   +1 more source

Computational neuroscience: a frontier of the 21^st century. [PDF]

Natl Sci Rev, 2020
Wang XJ, Hu H, Huang C, Kennedy H, Li CT, Logothetis N, Lu ZL, Luo Q, Poo MM, Tsao D, Wu S, Wu Z, Zhang X, Zhou D.   +13 more
europepmc   +1 more source

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

Novel applications of machine learning and computational neuroscience models to neuroimaging in Parkinson's disease and related disorders. [PDF]

Front Aging Neurosci
Chougar L, Vo A, Lehéricy S, Dagher A.
europepmc   +1 more source

Probabilistic Lesion Mapping to Optimize Thalamotomy Targets for Focal Hand Dystonia

Annals of Neurology, EarlyView.
Objective Focal hand dystonia (FHD) severely impairs task‐specific motor control, yet the optimal surgical target for stereotactic intervention remains uncertain. This study aimed to identify the precise thalamic lesion site associated with symptomatic improvement and to clarify its network connectivity. Methods We retrospectively analyzed 164 patients
Masahiko Nishitani, Shiro Horisawa, Konstantin Butenko, Hiroki Togo, Arun Garimella, William Drew, Melissa Chua, Esraa Shaban, Takakazu Kawamata, Takaomi Taira, Andreas Horn, Michael D. Fox, Takashi Hanakawa   +12 more
wiley   +1 more source

Multiplexed Tandem Mass Spectrometry Imaging Enables Large‐Scale Isomer Mapping and Annotation in Tissues

Angewandte Chemie, EarlyView.
Parallel mass spectrometry imaging acquires high mass resolution and tandem mass spectrometry images from 108 isolation windows in a single run. Spatial similarity networking clusters product ions by spatial distribution, enabling annotation of isomers and isobars as demonstrated for phospholipids and oxidized cholesterol in mouse and human brain ...
Varun V. Sharma, Gabor Toth, Robert Martinis, Cathrin E. Hansen, Gijs Kooij, Ingela Lanekoff   +5 more
wiley   +2 more sources

Editorial: Neuromorphic and deep learning paradigms for neural data interpretation and computational neuroscience. [PDF]

Front Comput Neurosci
Zou C, Yuan R, Wen J.
europepmc   +1 more source

Clot Composition Profiling in Large Vessel Occlusion Stroke Via Radiomics

Annals of Neurology, EarlyView.
Objective Clot composition may offer insights into the mechanism of ischemic stroke. Radiomics, a noninvasive imaging technique, enables tissue characterization through radiomic features (RFs). We aimed to evaluate clot composition using radiomics on non‐contrast computed tomography (NCCT).
Andres Gudino, Elena Sagues, Carlos Dier, Diego Ojeda, Samantha Saenz‐Hinojosa, Sebastian Sanchez, Ariel Vargas, Linder Wendt, Maria Belen Torres, Emily Garces, Alex Hanson, Navami Shenoy, Connor Aamot, Susan A. Walsh, Anil K. Chauhan, Gowri Anil‐Peethambar, Santiago Ortega‐Gutierrez, Jay Kinariwala, Mohamed Elshikh, Amir Shaban, Enrique C. Leira, Osorio Lopes Abath Neto, Malik Ghannam, Edgar A. Samaniego   +23 more
wiley   +1 more source

Second‐Generation Crystalline Sponges Enabling Consistent Structure Analysis Under Standardized Conditions for Diverse Molecules

Angewandte Chemie, EarlyView.
The second‐generation crystalline sponge method allows structurally diverse molecular guests to crystallize under standardized crystallization conditions. The key is the predominant packing type of cages and anions in crystals. ABSTRACT Crystallization is typically highly sensitive to even minor structural differences in target molecules.
Wei He, Hiroki Takezawa, Makoto Fujita
wiley   +2 more sources

Tau Pathology in Alzheimer's Disease Uniquely Affects Sulcal Depths

Annals of Neurology, EarlyView.
Objective Though it is widely known that tau deposition affects brain structure, the precise localization of these effects is poorly understood, especially in relation to gyral and sulcal anatomy. We investigated whether tau pathology in Alzheimer's disease (AD) preferentially affects sulci, and particularly sulcal depths.
Samira A. Maboudian, Corrina S. Fonseca, Adam C. Martersteck, Yishu Chao, Yuheng Chen, Daniela Ushizima, Duygu Tosun, Lea T. Grinberg, Kevin S. Weiner, William J. Jagust, for the Alzheimer's Disease Neuroimaging Initiative   +10 more
wiley   +1 more source