Results 151 to 160 of about 2,017,547 (269)

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Computational neuroscience [PDF]

Current Opinion in Neurobiology, 2019
Doiron, Brent, Lengyel, Máté
  +5 more sources

From Neurovascular Compression to Neural Hyperexcitability: Integrating Microanatomy, Electrophysiology, and Computational Neuroscience to Understand Trigeminal Neuralgia and Hemifacial Spasm. [PDF]

Cells
Okuhata H, Aihara M, Oya S, Nagai R, Aizawa K.   +4 more
europepmc   +1 more source

Computational neuroscience: a frontier of the 21^st century. [PDF]

Natl Sci Rev, 2020
Wang XJ, Hu H, Huang C, Kennedy H, Li CT, Logothetis N, Lu ZL, Luo Q, Poo MM, Tsao D, Wu S, Wu Z, Zhang X, Zhou D.   +13 more
europepmc   +1 more source

Modeling and Analysis of Data-Driven Systems through Computational Neuroscience Wavelet-Deep Optimized Model for Nonlinear Multicomponent Data Forecasting. [PDF]

Comput Intell Neurosci, 2021
Jin XB, Zhang JH, Su TL, Bai YT, Kong JL, Wang XY.   +5 more
europepmc   +1 more source

Are there morpho‐acoustic patterns of adaptation in nonhuman primate ears? Testing the role of ecology and habitat in shaping ear morphology and function

The Anatomical Record, EarlyView.
Abstract Analysis of the variation in the bony structures of the inner and middle ear provides critical insights into functional morphology, as well as adaptive morphology across primates. In this study, we investigated whether ear morphology patterns are related to the ecological characteristics of species and their habitats to test two acoustic ...
Myriam Marsot, Rémi Laffont, Émilie Steimetz, Patricia Balaresque, Sébastien Couette   +4 more
wiley   +1 more source

Editorial: Neuromorphic and deep learning paradigms for neural data interpretation and computational neuroscience. [PDF]

Front Comput Neurosci
Zou C, Yuan R, Wen J.
europepmc   +1 more source

Morphological and morphometric aspects of the equine aortic valve: New insights for comparative studies in mammals

The Anatomical Record, EarlyView.
Abstract New data on the equine aortic valve obtained using advanced techniques is especially important given the greater availability of animal models for translational research. Here we characterized the morphological and morphometric aspects of the equine aortic valve from 60 healthy hearts collected at equine abattoirs.
Vitor Pires Pereira, Victoria Brondani de Oliveira, Carlos Eduardo Seyfert, Luciano de Morais‐Pinto   +3 more
wiley   +1 more source

Novel applications of machine learning and computational neuroscience models to neuroimaging in Parkinson's disease and related disorders. [PDF]

Front Aging Neurosci
Chougar L, Vo A, Lehéricy S, Dagher A.
europepmc   +1 more source

Multi‐method analysis for the three‐dimensional reconstruction of muscle fascicles from DiceCT datasets

The Anatomical Record, EarlyView.
Abstract Muscle architecture is a major determinant of muscle performance and, in mammalian lineages, has been correlated with both feeding ecology and locomotor behaviors. Over the past decade, contrast‐enhanced micro‐CT (DiceCT) has emerged as an alternative to traditional dissection‐based measurement.
Aleksandra Ratkiewicz, Michael C. Granatosky, Cassidy E. Davis, Julia Molnar, Adam Hartstone‐Rose, Edwin Dickinson   +5 more
wiley   +1 more source