Results 101 to 110 of about 109,371 (286)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen +7 more
wiley +1 more source
Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem +17 more
wiley +1 more source
AiiDA: automated interactive infrastructure and database for computational science
Computational science has seen in the last decades a spectacular rise in the scope, breadth, and depth of its efforts. Notwithstanding this prevalence and impact, it is often still performed using the renaissance model of individual artisans gathered in ...
Pizzi, Giovanni +4 more
core +1 more source
How networks shape diversity for better or worse
Royal Society Open ScienceSocio-diversity, the variety of human opinions, ideas, behaviours and styles, has profound implications for social systems. While it fuels innovation, productivity and collective intelligence, it can also complicate communication and erode trust. So what
Andrea Musso, Dirk Helbing
doaj +1 more source
Computational Social Science in "Science" and "Nature"
, 2021 The growth of Computational Social Science as a subject that encompasses a variety of disciplines, topics, and methods has seen a dramatic increase over the last period. New entrants into this trans-disciplinary field come from a variety of disciplines and interests causing disruption, a re-questioning of accepted principles, and sometimes down-right ...
openaire +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang +8 more
wiley +1 more source
, 2023 Link zum MOOC: https://imoox.at/course/COSS Kursinhalt In diesem Kurs lernen Sie Digitale Datenerhebung, Datenmanagement und digitale Datenanalyseverfahren der Computational-Social-Science-Forschung kennen, relevante rechtliche, ethische und gesellschaftliche Fragen werden erklärt, Sie erhalten einen Einblick in Anwendungsbeispiele interdisziplinärer ...
openaire +1 more source
Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source
Handbook of Computational Social Science, Vol 1
, 2021 "The Handbook of Computational Social Science is a comprehensive reference source for scholars across multiple disciplines. It outlines key debates in the field, showcasing novel statistical modeling and machine learning methods, and draws from specific ...
core