Results 111 to 120 of about 1,551,089 (266)
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Theory In, Theory Out: The uses of social theory in machine learning for social science [PDF]
arXiv, 2020 Research at the intersection of machine learning and the social sciences has provided critical new insights into social behavior. At the same time, a variety of critiques have been raised ranging from technical issues with the data used and features constructed, problematic assumptions built into models, their limited interpretability, and their ...
arxiv
Big Data & Society, 2018 This paper argues that analyses of the ways in which Big Data has been enacted in other academic disciplines can provide us with concepts that will help understand the application of Big Data to social questions.
A. Bartlett +3 more
semanticscholar +1 more source
Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations
FEBS Open Bio, Volume 15, Issue 5, Page 699-713, May 2025.We used molecular dynamics simulations to test models proposing that synaptotagmin‐1 facilitates membrane fusion by perturbing lipid bilayers, inducing membrane curvature and/or bridging membranes. The simulations show that synaptotagmin‐1 C2‐domains placed near the site of fusion hinder the ability of SNARE complexes to bring the membranes together ...
Josep Rizo +2 more
wiley +1 more source
Computational Social Science: Discovery and Prediction
Analytical Methods for Social Research, 2016 Preface Gary King Introduction R. Michael Alvarez Part I. Computation Social Science Tools: 1. The application of big data in surveys to the study of public opinion, elections, and representation Christopher Warshaw 2.
R. M. Alvarez
semanticscholar +1 more source
FEBS Open Bio, EarlyView.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli +15 more
wiley +1 more source
FEBS Open Bio, EarlyView.ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren +8 more
wiley +1 more source
Effect of Social Media on Website Popularity: Differences between Public and Private Universities in Indonesia [PDF]
World of Computer Science and Information Technology Journal
(WCSIT), ISSN: 2221-0741, Vol. 3, No. 2, pp. 32-37, 2013, 2014 Social media has become something that is important to enhance social networking and sharing of information through the website. Social media have not only changed social networking, they provide a valuable tool for social organization, activism, political, healthcare and even academic relations in the university.
arxiv
How networks shape diversity for better or worse
Royal Society Open ScienceSocio-diversity, the variety of human opinions, ideas, behaviours and styles, has profound implications for social systems. While it fuels innovation, productivity and collective intelligence, it can also complicate communication and erode trust. So what
Andrea Musso, Dirk Helbing
doaj +1 more source
Inferring colocation and conversation networks from privacy-sensitive audio with implications for computational social science [PDF]
, 2011 Danny Wyatt +3 more
openalex +1 more source