Results 41 to 50 of about 92,985 (260)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

COMPUTABLE TOPOLOGICAL PRESENTATIONS

The Journal of Symbolic Logic
Abstract A computable topological presentation of a space is given by an effective list of a countable basis of non-empty open sets so that the intersection of the basic sets is uniformly effectively enumerable. We show that every countably-based
ALEXANDER MELNIKOV, KENG MENG NG, MATHIEU HOYRUP   +2 more
openaire   +2 more sources

On the computability of the topological entropy of subshifts [PDF]

Discrete Mathematics & Theoretical Computer Science, 2006
We prove that the topological entropy of subshifts having decidable language is uncomputable in the following sense: For no error bound less than 1/4 does there exists a program that, given a decision procedure for the language of a subshift as input, will approximate the entropy of the subshift within the error bound.
openaire   +4 more sources

The Realization of 3D Topological Spaces Branched over Graphs

International Journal of Topology
In this paper we present an implementation of a computer algorithm that automatically determines the topological structure of spacetime, using a branched covering space representation.
Christopher L. Duston
doaj   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

Certain topological methods for computing digital topological complexity

, 2021
In this paper, we examine the relations of two closely related concepts, the digital Lusternik-Schnirelmann category and the digital higher topological complexity, with each other in digital images. For some certain digital images, we introduce $κ-$topological groups in the digital topological manner for having stronger ideas about the digital higher ...
Is, Melih, Karaca, Ismet
openaire   +5 more sources

Phase Field Failure Modeling: Brittle‐Ductile Dual‐Phase Microstructures under Compressive Loading

Advanced Engineering Materials, EarlyView.
The approach by Amor and the approach by Miehe and Zhang for asymmetric damage behavior in the phase field method for fracture are compared regarding their fitness for microcrack‐based failure modeling. The comparison is performed for the case of a dual‐phase microstructure with a brittle and a ductile constituent.
Jakob Huber, Jan Torgersen, Ewald Werner
wiley   +1 more source

Microstructure‐Controlled Crack Propagation and Fracture Resistance in MoSiBTiC Alloy Revealed by Multiscale Extended Finite Element Method Modeling

Advanced Engineering Materials, EarlyView.
A two‐dimensional multiscale finite element analysis framework was established for the first‐generation MoSiBTiC alloy, and the mechanical and fracture‐related parameters of the constituent phases were calibrated through experiments and simulations. The framework provides a basis for analyzing crack propagation behavior in its complex microstructure ...
Junfeng Du, Takahiro Kaneko, Xinyu Yan, Takahito Ohmura, Kyosuke Yoshimi   +4 more
wiley   +1 more source

The topology of local computing in networks

Journal of Applied and Computational Topology
Modeling distributed computing in a way enabling the use of formal methods is a challenge that has been approached from different angles, among which two techniques emerged at the turn of the century: protocol complexes, and directed algebraic topology. In both cases, the considered computational model generally assumes communication via shared objects,
Fraigniaud, Pierre, Paz, Ami
openaire   +5 more sources

Computational intractability law molds the topology of biological networks

Applied Network Science, 2020
Virtually all molecular interaction networks (MINs), irrespective of organism or physiological context, have a majority of loosely-connected ‘leaf’ genes interacting with at most 1-3 genes, and a minority of highly-connected ‘hub’ genes interacting with ...
Ali A. Atiia, Corbin Hopper, Katsumi Inoue, Silvia Vidal, Jérôme Waldispühl   +4 more
doaj   +1 more source