Results 101 to 110 of about 73,306 (292)

Comprehensive computational analysis via Adverse Outcome Pathways and Aggregate Exposure Pathways in exploring synergistic effects from radon and tobacco smoke on lung cancer

Frontiers in Public Health
Lung cancer remains the leading cause of cancer mortality worldwide, with tobacco smoke and radon exposure being the primary risk factors. The interaction between these two factors has been described as sub-multiplicative, but a better understanding is ...
Thomas Jaylet, Vinita Chauhan, Laura Mezquita, Nadia Boroumand, Olivier Laurent, Karine Elihn, Lovisa Lundholm, Olivier Armant, Karine Audouze   +8 more
doaj   +1 more source

Per‐ and polyfluoroalkyl substances and knee osteoarthritis: data from the Osteoarthritis Initiative

Arthritis &Rheumatology, Accepted Article.
Objective To examine whether concentrations of specific per‐ and polyfluoroalkyl substances (PFAS) and a mixture of PFAS relate to incident knee osteoarthritis (KOA) and knee pain progression. Methods Among a case‐cohort sample from the Osteoarthritis Initiative (n=1,878), we examined associations of serum concentrations of 8 PFAS with odds of ...
Jeffrey B. Driban, Lisa B. Rokoff, Bing Lu, Timothy E. McAlindon, Charles B. Eaton, Mary B. Roberts, Diana Mathes, Colleen Lestician, Zhijin Carrie Xu, Zhihua Tina Fan, Shawn P. O'Leary, Ida K. Haugen, Jérémie Sellam, Alice Courties, Abby F. Fleisch   +14 more
wiley   +1 more source

Artificial Intelligence and Machine Learning Models for Predicting Drug-Induced Kidney Injury in Small Molecules

Pharmaceuticals
Background/Objectives: Drug-Induced Kidney Injury (DIKI) presents a significant challenge in drug development, often leading to clinical-stage failures. The early prediction of DIKI risk can improve drug safety and development efficiency. Existing models
Mohan Rao, Vahid Nassiri, Sanjay Srivastava, Amy Yang, Satjit Brar, Eric McDuffie, Clifford Sachs   +6 more
doaj   +1 more source

Advanced nanotherapeutics for combating ocular infections: Rational design, antimicrobial mechanisms, and therapeutic breakthroughs

BMEMat, EarlyView.
Nanomaterials revolutionize ocular infection treatment by enabling targeted drug delivery and enhanced antimicrobial efficacy against resistant pathogens. This review systematically explores their rational design, multimodal mechanisms, and translational potential for next‐generation anti‐infective therapies.
Yujia Liu, Xuetian Wen, Yue Tan, Rui Zeng, Yijuan Zhang, Tong Lin, Lan Gong, Zichao Luo   +7 more
wiley   +1 more source

TAME 2.0: expanding and improving online data science training for environmental health research

Frontiers in Toxicology
IntroductionData science training has the potential to propel environmental health research efforts into territories that remain untapped and holds immense promise to change our understanding of human health and the environment.
Alexis Payton, Alexis Payton, Alexis Payton, Elise Hickman, Elise Hickman, Elise Hickman, Jessie Chappel, Jessie Chappel, Jessie Chappel, Kyle Roell, Kyle Roell, Lauren E. Koval, Lauren E. Koval, Lauren A. Eaves, Lauren A. Eaves, Chloe K. Chou, Chloe K. Chou, Chloe K. Chou, Allison Spring, Allison Spring, Sarah L. Miller, Sarah L. Miller, Sarah L. Miller, Oyemwenosa N. Avenbuan, Oyemwenosa N. Avenbuan, Oyemwenosa N. Avenbuan, Rebecca Boyles, Rebecca Boyles, Paul Kruse, Cynthia V. Rider, Grace Patlewicz, Caroline Ring, Cavin Ward-Caviness, David M. Reif, Ilona Jaspers, Ilona Jaspers, Ilona Jaspers, Ilona Jaspers, Ilona Jaspers, Rebecca C. Fry, Rebecca C. Fry, Rebecca C. Fry, Julia E. Rager, Julia E. Rager, Julia E. Rager, Julia E. Rager   +45 more
doaj   +1 more source

The influence of rivers on seabird foraging ecology

Biological Reviews, EarlyView.
ABSTRACT Rivers act as vital arteries to the world's oceans, delivering fresh water and nutrients that sustain marine ecosystems. Globally, river flow increasingly is being altered by climate change and anthropogenic pressures; yet the significance of rivers to predatory marine species, such as seabirds, and the extent to which river‐related changes ...
Julia B. Morais, Andre Chiaradia, Richard D. Reina   +2 more
wiley   +1 more source

Identifying and Prioritizing Chemicals with Uncertain Burden of Exposure: Opportunities for Biomonitoring and Health-Related Research. [PDF]

, 2019
BackgroundThe National Institutes of Health's Environmental influences on Child Health Outcomes (ECHO) initiative aims to understand the impact of environmental factors on childhood disease. Over 40,000 chemicals are approved for commercial use.
(Environmental influences on Child Health Outcomes), Beamer, Paloma I, Bennett, Deborah H, Boyles, Rebecca R, Buckley, Jessie P, Kannan, Kurunthachalam, Pellizzari, Edo D, Wang, Aolin, Woodruff, Tracey J, Zhu, Yeyi   +9 more
core  

Stakeholder Engagement as a Design Principle: Orchestrating a Digital Platform for the Safety and Sustainability of the Nanomaterials Sector

Business Strategy and the Environment, EarlyView.
ABSTRACT The governance of chemicals and nanomaterials presents a critical challenge, as significant uncertainties regarding safety and sustainability match their innovation potential. This creates a “knowledge‐to‐action” gap, hindering the practical implementation of safety and sustainability by design (SSbD) principles.
Mario Miozza, Luigi Mersico, Jelena Barbir, Genc Alimehmeti, Angelo Paletta   +4 more
wiley   +1 more source

Chemical Reactivity and Skin Sensitization Studies on a Series of Chloro- and FluoropyrrolesA Computational Approach

ACS Omega, 2021
Jaganathan Padmanabhan, Zeeshan Arif, Prakrity Singh, Ramakrishnan Parthasarathi   +3 more
doaj   +1 more source

Transitioning Formamide Solvothermal Syntheses of MOFs to Less Toxic Solvents

Chemistry – A European Journal, EarlyView.
Metal‐organic Frameworks (MOFs) are commonly synthesized in toxic formamide solvents. This study investigates the synthetic factors required for effective removal of formamides across various classes of MOFs, providing a foundation for designing new sustainable MOF syntheses.
Julia C. Donovan, Evelyn C. Peterson, Adam J. Matzger   +2 more
wiley   +1 more source