Results 131 to 140 of about 72,918 (293)

Modeling Supports Combinatorial Effects Between Pharmacological and Non‐Pharmacological Interventions to Prevent Opioid‐Induced Cardiac Arrest

Clinical Pharmacology &Therapeutics, EarlyView.
Few studies have quantified the effects of non‐pharmacological interventions (e.g., rescue breathing) in the setting of community opioid overdose. We extended a previously validated model for opioid antagonists by incorporating the mechanism of rescue breathing, and quantified combinatorial effects between rescue breathing and various formulations of ...
Bradlee Thrasher, John Mann, Anik Chaturbedi, Shilpa Chakravartula, Hamed Meshkin, Affan Affan, Alexander Galluppi, Ji Young Kim, Nigar Karimli, Yue Han, Zachary Dezman, Jeffry Florian, Zhihua Li   +12 more
wiley   +1 more source

Optimizing androgen receptor prioritization using high-throughput assay-based activity models

Frontiers in Toxicology
Introduction: Computational models using data from high-throughput screening assays have promise for prioritizing and screening chemicals for testing under the U.S. Environmental Protection Agency’s Endocrine Disruptor Screening Program (EDSP).
Ronnie Joe Bever, Stephen W. Edwards, Todor Antonijevic, Mark D. Nelms, Caroline Ring, Danni Harris, Scott G. Lynn, David Williams, Grace Chappell, Rebecca Boyles, Susan Borghoff, Kristan J. Markey   +11 more
doaj   +1 more source

Carbon Dots: An Emerging Frontier for Green and Sustainable Civil Engineering Materials

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Traditional civil engineering materials (CE materials) are usually involved with high‐energy consumption during manufacturing, significant maintenance costs, and substantial environmental impacts throughout their life cycles. The progress of nanotechnology is catalyzing a green and sustainable transformation within the field.
Weiwen Hao, Xiaolong Wang, Xiao Chen, Dong Liu, Zhenhui Kang, Cheng Zhu   +5 more
wiley   +1 more source

New techniques and methods for study of environmental health effects

环境与职业医学
The health effects associated with environmental pollutants remain one of the major public health issues at present. The research method focusing on the population as the research subjects is limited by reliable cohorts, and the research method targeting
Xianan ZHANG, Shenshen WU, Qingtao MENG, Xiaobo LI, Rui CHEN, Hanqing CHEN   +5 more
doaj   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Artificial Intelligence in Cosmetic Formulation: Predictive Modeling for Safety, Tolerability, and Regulatory Perspectives

Cosmetics
Artificial intelligence (AI) and machine learning (ML) are increasingly transforming the landscape of cosmetic formulation, enabling the development of safer, more effective, and personalized products.
Antonio Di Guardo, Federica Trovato, Carmen Cantisani, Annunziata Dattola, Steven P. Nisticò, Giovanni Pellacani, Alessia Paganelli   +6 more
doaj   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Computational Tools to Facilitate Early Warning of New Emerging Risk Chemicals

Toxics
Innovative tools suitable for chemical risk assessment are being developed in numerous domains, such as non-target chemical analysis, omics, and computational approaches. These methods will also be critical components in an efficient early warning system
Farina Tariq, Lutz Ahrens, Nikiforos A. Alygizakis, Karine Audouze, Emilio Benfenati, Pedro N. Carvalho, Ioana Chelcea, Spyros Karakitsios, Achilleas Karakoltzidis, Vikas Kumar, Liadys Mora Lagares, Dimosthenis Sarigiannis, Gianluca Selvestrel, Olivier Taboureau, Katrin Vorkamp, Patrik L. Andersson   +15 more
doaj   +1 more source

Outcome of IWGT workshop on transcriptomic biomarkers for genotoxicity: Key considerations for bioinformatics

Environmental and Molecular Mutagenesis, EarlyView.
Abstract As a part of the International Workshop on Genotoxicity Testing (IWGT) in 2022, a workgroup was formed to evaluate the level of validation and regulatory acceptance of transcriptomic biomarkers that identify genotoxic substances. Several such biomarkers have been developed using various molecular techniques and computational approaches. Within
Matthew J. Meier, Florian Caiment, J. Christopher Corton, Roland Frötschl, Yurika Fujita, Danyel Jennen, Roman Mezencev, Carole Yauk   +7 more
wiley   +1 more source

Bridging science and curriculum: preparing future leaders in computational toxicology

Frontiers in Toxicology
Computational toxicology plays an important role in chemical safety assessments. Computational methods are applied to early-stage screening in drug discovery, hazard identification, and regulatory safety assessment.
Frances Hall, Candice Johnson
doaj   +1 more source