Results 141 to 150 of about 1,723,253 (280)
Clinical Pharmacology &Therapeutics, EarlyView.The NAT2 pharmacogene is essential in drug metabolism, particularly for aromatic amines and hydrazines. Genetic variations in NAT2 categorize individuals as rapid, intermediate, or poor metabolizers based on their acetylation capacity to inform dosing guidelines.
Shobana John +4 more
wiley +1 more source
Hybrid Computational Toxicology Models for Regulatory Risk Assessment [PDF]
, 2015 Computational toxicology is the development of quantitative structure activity relationship (QSAR) models that relate a quantitative measure of chemical structure to a biological effect.
Pradeep, Prachi
core
Advancing Pregnancy and Pediatric Science through the NIH Transporter Elucidation Network
Clinical Pharmacology &Therapeutics, EarlyView.Human gestation is characterized by dynamic changes in maternal physiology and maturation of tissue functions before and after birth. The fetus and neonate are highly dependent upon transfer of maternal nutrients via the placenta and lactating mammary gland, which frequently involve selective membrane transporter proteins.
Joanne Wang +16 more
wiley +1 more source
Use of computational toxicology tools to predict <i>in vivo</i> endpoints associated with Mode of Action and the endocannabinoid system: A case study with chlorpyrifos, chlorpyrifos-oxon and <sup>Δ9</sup>Tetrahydrocannabinol. [PDF]
Curr Res Toxicol, 2022 Silva M, Kwok RK.
europepmc +1 more source
Overview of Regulatory Guidelines Related to Methods and Models for Small Populations
Clinical Pharmacology &Therapeutics, EarlyView.This paper provides an overview of approaches and related guidelines from the EMA, FDA, and ICH that are relevant for obtaining clinical evidence for small populations to support regulatory decision making. The approaches are grouped into three categories: (1) maximizing the attainable sample size, (2) adapting the trial design to deal with a small ...
Laurens Sluijterman +6 more
wiley +1 more source
Niobium‐Based Chalcogenides as Emerging Electrode Materials for Rechargeable Batteries
EcoEnergy, EarlyView.This review highlights recent advances in Nb‐based TMCs, covering their structure‐property relationships, synthesis strategies, electrochemical mechanisms, and energy‐storage applications. Emerging approaches including defect engineering, operando characterization, DFT modeling, and AI‐assisted design are discussed to accelerate the development of high‐
Narasimharao Kitchamsetti +3 more
wiley +1 more source
Epilepsia Open, EarlyView.Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar +4 more
wiley +1 more source
Environmental Toxicology and Chemistry, EarlyView.Abstract The EcoToxChip project includes RNA‐sequencing data from experiments involving model (Japanese quail, fathead minnow, African clawed frog) and ecological (double‐crested cormorant, rainbow trout, northern leopard frog) species at multiple life stages (whole embryo and adult) exposed to eight chemicals of environmental concern known to perturb ...
Krittika Mittal +7 more
wiley +1 more source
Navigating the Minefield of Computational Toxicology and Informatics: Looking Back and Charting a New Horizon. [PDF]
Front Toxicol, 2020 Patlewicz G.
europepmc +1 more source
Exercising electrocardiograms from Thoroughbred racehorses with exercise associated sudden death
Equine Veterinary Journal, EarlyView.Abstract Background Exercise associated sudden death (EASD), defined as a fatal collapse in a closely monitored and previously presumed clinically healthy horse that occurs during exercise or within approximately 1 h after exercise, is disproportionately more common in equine than in human athletes.
Cristobal Navas de Solis +3 more
wiley +1 more source