Results 131 to 140 of about 1,723,253 (280)
From Caffeine to Aspirin: Everyday Molecules as Triggers for Genetically Encoded Proximity Systems
Chemistry – A European Journal, EarlyView.This Perspective article highlights how familiar dietary ingredients and over‐the‐counter (OTC) drugs (such as caffeine and its metabolites, SA, and aspirin) can be repurposed as clinically translatable chemical triggers for genetically encoded proximity systems.
Mingguang Cui +5 more
wiley +1 more source
ToxicsSkin sensitization is a significant concern for chemical safety assessments. Traditional animal assays often fail to predict human responses accurately, and ethical constraints limit the collection of human data, necessitating a need for reliable in ...
Ricardo Scheufen Tieghi +8 more
doaj +1 more source
In Vitro and Predictive Computational Toxicology Methods for the Neurotoxic Pesticide Amitraz and Its Metabolites. [PDF]
Brain Sci, 2023 Giorgini M +4 more
europepmc +1 more source
Chemistry – A European Journal, EarlyView.Hydrogen‐release processes in silicon chemistry occur across a broad spectrum of systems, including crystalline silicon surfaces, nanoporous materials, Zintl phases, and molecular hydrides. This Review highlights how Si─H activation and H2 evolution are governed by structure, coordination environment, and dynamic access to reactive geometries, with ...
Robin Rothfelder, Jonathan O. Bauer
wiley +1 more source
American College of Medical Toxicology
The American College of Medical Toxicology (ACMT) is a professional, nonprofit association of physicians with recognized expertise in medical toxicology, whose mission is to ensure that patients exposed to poisons and toxic substances receive optimal ...
core +1 more source
Chemistry – A European Journal, EarlyView.Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi +6 more
wiley +1 more source
Decoding cellular stress states for toxicology using single-cell transcriptomics
NAM JournalWe applied the TempO-LINC® platform to generate single-cell transcriptomic (SCTr) profiles of ∼40,000 HepaRG cells exposed to etoposide, brefeldin A, cycloheximide, rotenone, tBHQ, troglitazone, and tunicamycin at three concentrations for 24 hours.
Imran Shah +14 more
doaj +1 more source
Trends and Future Directions in Organic Chemistry for Drug Discovery
Chemistry – A European Journal, EarlyView.Organic synthesis is being reshaped by the convergence of catalytic innovation, automation, artificial intelligence, and emerging therapeutic modalities. Late‐stage functionalization, photoredox and electrochemical methods, biocatalysis, flow chemistry, DELs, and proximity‐based drugs are examined as components of closed‐loop discovery.
Paweł Kozyra, Maciej Masłyk
wiley +1 more source
The Canadian Journal of Chemical Engineering, EarlyView.Abstract On the centennial of higher education in Chemical Engineering in Mexico, it is pertinent to revisit the key stages that have contributed to its consolidation as a vital discipline for the nation's scientific and technological advancement. Although the initial mission of chemical engineering education was primarily oriented toward the training ...
Agustín López Munguía +3 more
wiley +1 more source
A lumped modelling framework for the epoxidation of vegetable oils and fatty acid methyl esters
The Canadian Journal of Chemical Engineering, EarlyView.Abstract Epoxidized vegetable oils and fatty acid methyl esters are promising bio‐based alternatives to phthalates for plasticizer applications. Their synthesis typically involves the reaction of unsaturated double bonds with peracetic acid in a biphasic liquid–liquid system, where the simultaneous occurrence of reaction and phase partitioning makes ...
Irene Presti +3 more
wiley +1 more source