Results 201 to 210 of about 2,703,446 (282)

Navigating complexity in modern toxicology: the role of omics in short-term in vivo studies. [PDF]

Toxicol Sci
Mitchell CA, Wehmas L, Rouquié D, Caiment F, Currie RA, Crute CE.   +5 more
europepmc   +1 more source

A Unified Whole Lung PBK Model for Inhalational Uptake of Gases and Aerosols in Men

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Assessing the risk or benefit of an inhaled substance is challenging due to the variety of forms it can take (gas, vapor, particle, or droplet) and the complex biological processes involved in its uptake and retention. Physiologically based kinetic (PBK) models offer an alternative to in vivo experiments.
Norman Nowak, Sylvia E. Escher, Katharina Schwarz   +2 more
wiley   +1 more source

Flavonoids as Anxiolytics in Animal Tests: Systematic Review, Meta‐Analysis, and Bibliometrical Analysis

Phytotherapy Research, EarlyView.
ABSTRACT Flavonoids are natural secondary metabolites of plants with a basic composition derived from polyphenols that can produce a plethora of different neurophysiological effects, some of which are relevant to anxiety disorders. As such, many flavonoids have been evaluated in behavioral screens in preclinical research on anxiolytics.
Jhennify Albuquerque Machado, Danilo Brandão Araújo, Monica Lima‐Maximino, Diógenes Henrique de Siqueira‐Silva, Bernardo Tomchinsky, Jonathan Cueto‐Escobedo, Juan Francisco Rodríguez‐Landa, Caio Maximino   +7 more
wiley   +1 more source

Editorial: Next generation chemical risk assessment: integration of advances in toxicology, biology and computation

Frontiers in Toxicology
Kan Shao, Kan Shao, Chao Ji, Bernard Gadagbui   +3 more
doaj   +1 more source

A Bayesian neural ordinary differential equations framework to study the effects of chemical mixtures on survival. [PDF]

PLoS Comput Biol
Baudrot V, Cedergreen N, Kleiber T, Gergs A, Charles S.   +4 more
europepmc   +1 more source

Nrf2‐Mediated Ferroptosis Is Involved in Berberine‐Induced Alleviation of Diabetic Kidney Disease

Phytotherapy Research, EarlyView.
ABSTRACT Diabetic kidney disease (DKD) is the most common and serious complication of diabetes mellitus. Currently, there is a lack of safe and effective preventive strategies for DKD. The study aimed to explore the preventive effects and potential mechanisms of berberine (BBR) against DKD.
Kun Gao, Yunhua Liu, Kun Li, Lin Liu, Yanmo Cai, Xinxue Zhang, Zongjiang Zhao   +6 more
wiley   +1 more source

ToxPoint: The indispensable role of zebrafish as a new approach methodology (NAM) in toxicology. [PDF]

Toxicol Sci
Tanguay RL.
europepmc   +1 more source

Profiling animal toxicants by automatically mining public bioassay data: a big data approach for computational toxicology. [PDF]

PLoS One, 2014
Zhang J, Hsieh JH, Zhu H.
europepmc   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

The OASIS Consortium: integrating multi-omics technologies to transform chemical safety assessment. [PDF]

Toxicol Sci
Rouquié D, Bender A, Cheah J, Crute CE, Dalmas D, Ewald J, Fullerton A, Harrill JA, Kadri S, Kleinstreuer N, Kramer N, LaRocca J, Mitchell CA, Seal S, Singh S, Carpenter AE.   +15 more
europepmc   +1 more source