Results 181 to 190 of about 3,045,461 (301)

Bio‐guided fractionation of (9Z)‐5,8,11‐trihydroxyoctadec‐9‐enoic acid from Abelmoschus sagittifolius root as a potent α‐glucosidase inhibitor: An integrated in vitro and in silico study

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Abelmoschus sagittifolius stands out as a valuable medicinal source for developing functional food targeting type 2 diabetes. This study investigated the α‐glucosidase inhibitory potential of an active fraction obtained from A. sagittifolius roots (ASR), enriched in (9Z)‐5,8,11‐trihydroxyoctadec‐9‐enoic acid (OA), using both enzyme ...
Nguyen Phuong Mai, Nguyen Van Quan, Nguyen Dang Duc, Tran Dang Xuan   +3 more
wiley   +1 more source

Pilot study on benzene exposure risks in healthcare workers: a combined socio-demographic and computational toxicology approach. [PDF]

Front Public Health
Zhang Y, Nisa WU, Rashid A, Saleem AR, Riaz L, Kalsoom S, Idris AM, Yu G, Ullah H.   +8 more
europepmc   +1 more source

Computational Toxicology is Now Inseparable from Experimental Toxicology [PDF]

Alternatives to Laboratory Animals, 2013
openaire   +2 more sources

Molecular Mechanism of the IRF1/NFE2L1‐DT/ALKBH5/Cx43 Axis in Radiation‐Induced Injury in Vascular Endothelial Cells Through Pyroptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li, Jia‐Wen Yang, Yong‐Rui Jia, Jie Zhang, Qiao Gou   +4 more
wiley   +1 more source

Evaluating the Enantioselective Neurotoxicity of Organophosphorus Pollutant Dioxabenzofos: Mechanistic Studies Employing Cellular, Molecular, and Computational Toxicology Assays. [PDF]

ACS Omega
He ZC, Zhang T, Lu XF, Li R, Mei Q, Wang QZ, Ding F, Peng W.   +7 more
europepmc   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

Exploring the Reproductive Toxicity of Bisphenol S Through a Network Toxicology and Molecular Docking Analysis

Pediatric Discovery, EarlyView.
Utilizing network toxicology, molecular docking, and dynamic simulations to investigate the potential reproductive toxicity of bisphenol S (BPS). ABSTRACT The aim of this study was to investigate the potential reproductive toxicity of bisphenol S (BPS) and the related molecular mechanisms through a network toxicology approach.
Siyuan Wang, Yan Fu, Xu Huang, Qitong Guo, Xiangqin Zheng, Shengde Wu, Lianju Shen, Guanghui Wei   +7 more
wiley   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

Computational Toxicology Methods in Chemical Library Design and High-Throughput Screening Hit Validation. [PDF]

Methods Mol Biol, 2018
Hevener KE.
europepmc   +1 more source

Advancing Sclerotinia risk forecasting for winter rapeseed in Germany: integrating crop phenology and disease development into a decision support system

Pest Management Science, EarlyView.
Integrating crop phenology and sclerotia germination models into SkleroPro improved Sclerotinia risk prediction accuracy from 34% to 66%, optimizing fungicide timing and supporting sustainable winter rapeseed production. Abstract BACKGROUND Sclerotinia stem rot, caused by Sclerotinia sclerotiorum, threatens winter rapeseed (Brassica napus) production ...
Vera Krause, Nazanin Zamani‐Noor, Lena Müller, Hella Kehlenbeck, Anto Raja Dominic   +4 more
wiley   +1 more source