Results 171 to 180 of about 3,045,461 (301)

Hydrogel‐based drug delivery systems for intracerebral hemorrhage with therapeutic advances and emerging roles of the bone–brain axis

Interdisciplinary Medicine, EarlyView.
Hydrogel‐based drug delivery systems offer a promising approach for treating intracerebral hemorrhage (ICH) by overcoming blood‐brain barrier limitations, enabling precise, sustained release of neuroprotective and anti‐inflammatory agents. These systems enhance treatment efficacy, but challenges remain in biosafety, drug penetration, and scalability ...
Haojun Shi, Min Chen, Yisheng Chen, MengYao Li, Jiale Ma, Zuozhen Yin, Li Wu, YangBao Miao, Zemin Ou, Ke Wu, Zhijie Xu, Lizhi Li, Shaocong Zhao, Shiwei He, Bin Huang, Guanwen He, Guanghui Wu, John H. Zhang, Liang Shi   +18 more
wiley   +1 more source

Immunomodulation of the Prostate Tumor Microenvironment Following Inorganic Arsenic Exposure

Journal of Applied Toxicology, EarlyView.
ABSTRACT The tumor microenvironment (TME) influences prostate cancer (PCa) progression through stromal and immune interactions. Adipose‐derived mesenchymal stromal cells (ASCs) modulate immune tone, while inorganic arsenic (iAs), a widespread toxicant, is linked to immune suppression and carcinogenesis.
Joseph J. Shearer, Cosette Rivera‐Cruz, Alexandre M. B. Cavalca, Carlos Eduardo Fonseca‐Alves, Marxa L. Figueiredo   +4 more
wiley   +1 more source

Unraveling the potential carcinogenic risk of bisphenols: a comprehensive network analysis and computational toxicology insights. [PDF]

Hum Genomics
Li T, Yan Z, Zhao W, Hou Y, Lv S, Zeng Z, Yang L, Zhou M, Zhang F, Ren X, Zhou Y, Zhu Z, Huang S, Yang M.   +13 more
europepmc   +1 more source

Framework for a Computational Toxicology Research Program

, 2003
56 pages; available for download at the link below.This document is intended to identify the research needs of the Agency and the unique capabilities of ORD laboratories to provide the basis for a more focused and integrated research program in the ...
United States Environmental Protection Agency Office of Research and Development
core  

Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza, Lara Rodrigues De Andrade, Tatiana da Silva Souza   +2 more
wiley   +1 more source

Heterogeneous Biological Responses to Low-Level Sodium Saccharin Exposure: An Integrated Computational Toxicology and Mendelian Randomization Study. [PDF]

Dose Response
Xin Z, Yanchun W, Xinwang C, Xuemei W.
europepmc   +1 more source

New Hydrazone Derivatives Featuring Isatin and Piperazine Moieties: Synthesis, Cytotoxicity Evaluation, and Molecular Modeling Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT In this study, ten novel compounds (IPH1–IPH10) were designed by integrating three pharmacophores (isatin, piperazine, and hydrazone) commonly found in the molecular structures of anticancer agents. The target molecules were obtained by the reaction of in‐house prepared 4‐(4‐(pyridin/pyrimidin‐2‐yl)piperazin‐1‐yl)benzohydrazide with various ...
Semiha Köprü, Münevver Baran, Miyase Gözde Gündüz, Şengül Dilem Doğan   +3 more
wiley   +1 more source

The use of activated carbon derived from spent coffee grounds as a reusable, sustainable, and effective solution for the removal of butylparaben from water

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Parabens, including butylparaben (BP), are widely used as antimicrobial preservatives in food, cosmetics, and pharmaceuticals, yet are poorly removed by conventional water treatment processes and pose potential risks to aquatic life and human health.
Lorena Maihury Santos Tsubouchi, Diane Scapin, Gideã Taques Tractz, Flávia Aparecida Reitz Cardoso, Lúcio Cardozo‐Filho, Alessandro Francisco Martins, Diógenes Vedoy, Ana Paula Peron, Osvaldo Valarini Junior   +8 more
wiley   +1 more source

Exploring Toxicological Mechanisms of Typical PFAS-Induced NAFLD through Integrated Computational Toxicology and AOP Frameworks. [PDF]

Environ Health (Wash)
Li F, Wang J, Liu Y, Sun T, Ji C, Wu H.
europepmc   +1 more source

Development of an Efficient and Scalable Process for Preparing Timolol N‐Nitrosamine Impurities B, C, E, H, I, J, and Their ADMET Evaluation

Journal of Heterocyclic Chemistry, EarlyView.
N‐nitrosamine impurities (B, C, E, H, I, J) of timolol maleate are easily synthesized from diethyl malonate and 3,4‐dichloro‐1,2,5‐thiadiazole. Good yields and precise impurity profiling are made possible by the effective technique, which also ensures pharmaceutical safety and strengthens regulatory compliance.
Kottolla Sai Prasad, Chithaluri Sudhakar, Vijaya Krishna Ravi, Bijaya Kethan Sahoo   +3 more
wiley   +1 more source