Results 221 to 230 of about 2,703,446 (282)

Leveraging the ADAM10 prodomain for selective inhibition to enhance recovery after myocardial infarction

British Journal of Pharmacology, EarlyView.
Background and Purpose Inflammation plays a crucial role in the development and progression of numerous acute and chronic diseases such as myocardial infarction (MI) and heart failure. Targeting ADAM proteases, particularly ADAM10, holds promise for fine‐tuning inflammatory responses.
Erik Klapproth, Johanna Marks, Patrick Diaba‐Nuhoho, Sören Grell, Paul Leubauer, Susanne Kämmerer, Johannes R. Soltwedel, Fred Rasmussen, Felix Mejia, Marcia L. Moss, Christopher Prince, Peter Mirtschink, Ben Wielockx, Paul Saftig, Michael Wagner, Kristina Lorenz, Ali El‐Armouche   +16 more
wiley   +1 more source

The computationally guided design of selective targeters of multiple proteins (STaMPs) as a new opportunity for small molecule drug discovery. [PDF]

Front Pharmacol
Kaiser TM.
europepmc   +1 more source

Prioritising research on endocrine disruption in the marine environment: a global perspective

Biological Reviews, EarlyView.
ABSTRACT A healthy ocean is a crucial life support system that regulates the global climate, is a source of oxygen and supports major economic activities. A vast and understudied biodiversity from micro‐ to macro‐organisms is integral to ocean health.
Patricia I. S. Pinto, Angelica Miglioli, Carlie A. LaLone, Lisa Baumann, Alice Baynes, Mélanie Blanc‐Legendre, Ibon Cancio, Xavier Cousin, ZhiChao Dang, Rémi Dumollard, Alex T. Ford, Christopher Green, Taisen Iguchi, Philippa Kearney, Thomas Knigge, Christophe Minier, Tiphaine Monsinjon, Marta S. Monteiro, Joachim Sturve, Haruna Watanabe, Hiroshi Yamamoto, Gerald Ankley, Deborah M. Power, Ioanna Katsiadaki   +23 more
wiley   +1 more source

A Risk-Based Framework for Hospital Compounding: Integrating Degradation Mechanisms and Predictive Toxicology. [PDF]

Pharmaceutics
Secretan PH, Annereau M, Do B.
europepmc   +1 more source

Effect of high‐speed exercise on subchondral bone in the metacarpo−/metatarsophalangeal joints of 2‐year‐old Thoroughbred racehorses in their first year of training

Equine Veterinary Journal, EarlyView.
Abstract Background Stress‐induced bone injury can lead to catastrophic injuries in Thoroughbred racehorses. Accumulation of high‐speed exercise can increase the risk of subchondral bone injury. Objectives To investigate the effect of high‐speed exercise on the subchondral bone of the metacarpo–metatarsophalangeal (MCP/MTP) joints using standing cone ...
Sarah A. Ciamillo, Kathryn W. Bills, Taryn M. Gassert, Dean W. Richardson, Kara A. Brown, Darko Stefanovski, Kyla F. Ortved   +6 more
wiley   +1 more source

The effect of acetyl tributyl citrate on coronary heart disease: a comprehensive computational analysis. [PDF]

BMC Pharmacol Toxicol
Ma X, Liu Y, Hua Z, Jiang F, Shi S, Wang K, Yu J, Zhang L.   +7 more
europepmc   +1 more source

The proteomic differences and expression of fatty acid‐binding protein 6 (FABP6) associated with gastrointestinal injury in horses with oral administration of a clinical dose of phenylbutazone

Equine Veterinary Journal, EarlyView.
Abstract Background Phenylbutazone (PBZ) can potentially induce gastrointestinal ulceration, and early detection of PBZ‐induced gastroenteropathy will be useful for the diagnosis, treatment, and prevention of PBZ toxicity. Objectives To identify putative proteins associated with equine gastric ulcer syndrome after clinical dose (4.4 mg/kg ...
Ruethaiwan Vinijkumthorn, Nawarus Prapaiwan, Thanapon Chotikaprakal, Phirom Prompiram, Narumon Phaonakrop, Sittiruk Roytrakul, Parichart Tesena   +6 more
wiley   +1 more source

Investigation of the toxic mechanism of aspartame on female infertility using network toxicology and molecular docking approaches. [PDF]

Medicine (Baltimore)
Yang T, Gao X, Pang X, Zhang L.
europepmc   +1 more source

Unwelcome neighbours: Tracking the transmission of Streptococcus equi in the United Kingdom horse population

Equine Veterinary Journal, EarlyView.
Abstract Background Strangles (Streptococcus equi infection) remains endemic in the UK, with ~300 laboratory diagnoses annually. Sub‐clinically infected long‐term carriers are considered a key driver of endemicity. Analysing genomes of circulating strains could provide valuable transmission insights of this pathogen.
Abigail A. McGlennon, Kristien L. Verheyen, J. Richard Newton, Andries van Tonder, Hayley Wilson, Julian Parkhill, Nicolas de Brauwere, Sara Frosth, Andrew S. Waller   +8 more
wiley   +1 more source