Results 221 to 230 of about 72,918 (293)

Spectroscopic Methods of Edible Flower Authentication and Quality Control for Food Applications

eFood, Volume 7, Issue 1, February 2026.
The global demand for edible flowers has increased. Issues such as incorrect species identification, flower product adulteration, contamination, and quality degradation necessitate the application of proper methods for authenticating and controlling the product's quality.
Fidele Benimana, Christopher Kucha, Anupam Roy, Anand Mohan   +3 more
wiley   +1 more source

Deciphering bisphenol A (BPA)-elicited osteoarthritis mechanisms through network toxicology and molecular docking, then de novo generation of novel therapeutic candidates. [PDF]

BMC Pharmacol Toxicol
Xu S, Jiang L, Zhang Z, Luo X, Wu W, Wu H, Huang Z, Falls Z, Samudrala R, Tan Z.   +9 more
europepmc   +1 more source

A Multimodal Approach to Identify Metallothionein Metal Inducers in Nile Tilapia: Insights From Molecular Docking and Hepatocyte Exposure

Journal of Applied Toxicology, Volume 46, Issue 2, Page 590-600, February 2026.
ABSTRACT Many human activities contribute to the pollution of aquatic ecosystems, primarily through agricultural, industrial, mining, and domestic discharges into water bodies. Fish, being highly sensitive to environmental changes, serve as valuable models for monitoring the health of these ecosystems.
Jessica Zablocki da Luz, Tugstênio Lima de Souza, Aliciane de Almeida Roque, Micheli de Marchi, Roberta Pozzan, Camila Confortin, Iracema Opuskevitch, Fernando Cesar Alves da Silva Ferreira, Ciro Alberto de Oliveira Ribeiro, Francisco Filipak Neto   +9 more
wiley   +1 more source

Water Networks as Hydrophobic Recognition Motifs in Proteins

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Hydrophobic groups can strengthen confined water networks, promoting order that propagates through the protein structure and drives recognition, creating a paradoxical hydrophobic binding hot spot. Polar groups are rejected because they disrupt the network, destabilizing the protein structure.
Serena G. Piticchio, Miriam Martínez‐Cartró, Salvatore Scaffidi, Sergio Rodríguez‐Arévalo, Andrea Bagán, Ainoa Sánchez‐Arfelis, Sarah Picaud, Tobias Krojer, Panagis Filippakopoulos, Frank von Delft, Carmen Escolano, Carles Galdeano, Xavier Barril   +12 more
wiley   +2 more sources

Navigating the AI Frontier in Toxicology: Trends, Trust, and Transformation. [PDF]

Curr Environ Health Rep
Luechtefeld T, Hartung T.
europepmc   +1 more source

Beyond the Michaelis–Menten: Evaluation of a tQSSA‐Based IVIVE Approach for Predicting In Vivo Intrinsic Clearance From Hepatocyte Assays

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT The classical Michaelis–Menten model, under the standard quasi‐steady‐state approximation (sQSSA), is widely used in in vitro‐in vivo extrapolation (IVIVE) studies using hepatocyte or human liver microsomal (HLM) assays to predict intrinsic hepatic clearance (Clint,vitro$$ {\mathrm{Cl}}_{\operatorname{int},\mathrm{vitro}} $$).
Ngoc‐Anh Thi Vu, Yun Min Song, Sang Kyum Kim, Hwi‐yeol Yun, Soyoung Lee, Jae Kyoung Kim, Jung‐woo Chae   +6 more
wiley   +1 more source

GSBS News, Spring 2006 [PDF]

, 2005
Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston/M.D. Anderson Cancer Center
core   +2 more sources

Validating Physiologically‐Based Pharmacokinetic Models Using the Continuous Ranked Probability Score: Beyond Being Correct on Average

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Physiologically‐based pharmacokinetic (PBPK) models have become increasingly popular for model‐informed drug development (MIDD) over the past decade. While several guidelines for model evaluation exist, these are by design often of a general and non‐specific nature. It is clear what steps should be carried out but not necessarily how.
Laurens Sluijterman, Marjolein van Borselen, Rick Greupink, Joanna IntHout   +3 more
wiley   +1 more source

Navigating complexity in modern toxicology: the role of omics in short-term in vivo studies. [PDF]

Toxicol Sci
Mitchell CA, Wehmas L, Rouquié D, Caiment F, Currie RA, Crute CE.   +5 more
europepmc   +1 more source

Identifying new targets in the fight against opioids. [PDF]

Elife
Laezza F.
europepmc   +1 more source