Results 31 to 40 of about 47,108 (219)

Analyzing positional accuracy and structural efficiency in additive manufacturing systems with moving elements

Results in Engineering
Simulation is a useful tool for designing and analyzing the characteristics of a system being investigated. In this investigation, modal simulation and harmonic response analysis are performed to predict the dynamic characteristics of an additive ...
Tzu-Chi Chan, Sai Vijay Medarametla, Ratnakar behera   +2 more
doaj   +1 more source

Microlens Array Fabrication by Using a Microshaper

Micromachines, 2021
A simple, easy, inexpensive, and quick nonsilicon-based micromachining method was developed to manufacture a microlens array. The spherical surface of the microlens was machined using a microshaper mounted on a three-axis vertical computer numerical ...
Meng-Ju Lin, Cheng Hao Wen
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

THE APPLICATION OF COMBINATORIAL-VARIATIONAL APPROACH TO COMPUTER GEOMETRICAL MODELING OF ENGINEERING CONSTRUCTIONS AND BUILDINGS

Structural Mechanics of Engineering Constructions and Buildings, 2013
The paper considers some issues of combinatorial-variational geometric modeling for computer-aided formation of engineering constructions and buildings in their design using modern computer-aided approach.
Vladimir VLADIMIROVICh Vanin, S L Shambina, Vadym GENNADIEVICh Virchenko   +2 more
doaj  

A two-stage multi-scale attention-based network for weakly supervised cataract fundus image enhancement

Scientific Reports
Cataract is a major cause of vision loss and hinders further diagnosis. However, enhancing cataract fundus images remains challenging due to limited paired cataract retinal images and the difficulty of recovering fine details in the retinal images.
Xiaoyong Fang, Yue Wang, Xiangyu Li, Wanshu Fan, Dongsheng Zhou   +4 more
doaj   +1 more source

Energy Integration and WEP Technical Evaluation of a Large-Scale PVC Production Process

Sci
PVC has become an indispensable material worldwide. However, its production method (suspension) presents significant sustainability challenges, such as negative environmental impacts and high operational costs due to energy consumption.
Antonio Mendivil-Arrieta, Eduardo Andres Aguilar-Vasquez, Juan Manuel Diaz-Perez, Miguel Ramos-Olmos, Ángel Darío Gonzaléz-Delgado   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source