Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Computer aided systems human engineering: A hypermedia tool [PDF]
The Computer Aided Systems Human Engineering (CASHE) system, Version 1.0, is a multimedia ergonomics database on CD-ROM for the Apple Macintosh II computer, being developed for use by human system designers, educators, and researchers.
Boff, Kenneth R. +2 more
core +1 more source
Pengelolaan Biaya Manufaktur pada Lingkungan Teknologi Manufaktur Maju [PDF]
, 2000 Tingginya tingkat persaingan yang terjadi sebagai akibat adanya globalisasi ekonomi mendorong Perusahaan untuk selalu unggul dalam persaingan. Salah satu alternatif penting yang perlu dipertimbangkan Perusahaan adalah penggunaan teknologi manufaktur maju
Sukarmanto, E. (Edi)
core
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Modal finite element correlation for computer aided engineering education
Engineering ReportsThe main challenge faced by many mechanical engineering educators is the implementation of real solutions during their courses. One alternative can be a realistic case study, where the students can be engaged in the development and analysis process ...
Moises Jimenez‐Martinez +3 more
doaj +1 more source
Multiple-choice tests in teaching software engineers : how applied and how applicable? [PDF]
, 2009 Although computer-aided assessment has been developed since late 1980’s, advantages and disadvantages of multiple-choice tests (MCTs), as opposed to traditional academic techniques (such as essays), are still greatly debated. This paper overviews current
Matveeva, Tamara
core
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Repurposing designed mutants: a valuable strategy for computer-aided laccase engineering – the case of POXA1b [PDF]
, 2017 The broad specificity of laccases, a direct consequence of their shallow binding site, makes this class of enzymes a suitable template to build specificity toward putative substrates.
Giacobelli, Valerio G. +6 more
core +2 more sources
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Providing Integrated Model of Fuzzy Hierarchical Analysis, Gray Relational Analysis and Multi-Objective Planning for Business Partner Selection [PDF]
چشمانداز مدیریت صنعتی, 2011 Today, as the population grows, industries are turning to technologies that can both accelerate production and improve product quality. Computer-aided design, production and engineering is one of the newest technologies used in a wide range of industries
Ali Mohammadi +2 more
doaj