Results 81 to 90 of about 423,955 (310)

Computer aided systems human engineering: A hypermedia tool [PDF]

open access: yes
The Computer Aided Systems Human Engineering (CASHE) system, Version 1.0, is a multimedia ergonomics database on CD-ROM for the Apple Macintosh II computer, being developed for use by human system designers, educators, and researchers.
Boff, Kenneth R.   +2 more
core   +1 more source

Design and structural optimisation of a tractor mounted telescopic boom crane [PDF]

open access: yes, 2016
In this research, an application algorithm, which can be used in computer-aided design/engineering (CAD/CAE) and structural optimisation-based design studies of agricultural machineries, is introduced. This developed algorithm has been put in practice in
Akinci, Ibrahim   +2 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Modal finite element correlation for computer aided engineering education

open access: yesEngineering Reports
The main challenge faced by many mechanical engineering educators is the implementation of real solutions during their courses. One alternative can be a realistic case study, where the students can be engaged in the development and analysis process ...
Moises Jimenez‐Martinez   +3 more
doaj   +1 more source

Innovative Structural Optimization and Dynamic Performance Enhancement of High-Precision Five-Axis Machine Tools

open access: yesJournal of Manufacturing and Materials Processing
To satisfy the requirements of five-axis processing quality, this article improves and optimizes the machine tool structure design to produce improved dynamic characteristics. This study focuses on the investigation of five-axis machine tools’ static and
Ratnakar Behera   +2 more
doaj   +1 more source

Temporal perception of visual-haptic events in multimodal telepresence system [PDF]

open access: yes, 2010
Book synopsis: Haptic interfaces are divided into two main categories: force feedback and tactile. Force feedback interfaces are used to explore and modify remote/virtual objects in three physical dimensions in applications including computer-aided ...
Muller, Hermann J., Shi, Z., Zou, H.
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Product Enhancement with a systems approach, utilising Time Compression Technologies [PDF]

open access: yes, 2006
In the current competitive market of introducing new products and processes it is absolutely vital to reduce lead times, produce a prototype which is right first time and produce design specifications which will ensure that the products are eventually ...
Hackney, Philip   +2 more
core  

On the Evolution of CAE Research [PDF]

open access: yes, 1994
Less than a decade ago it seemed that a new paradigm of engineering–called computer-aided engineering (CAE) – was emerging. This emergence was driven in part by the success of computer support for the tasks of engineering analysis and in part by a new ...
Dym, Clive L., Levitt, Raymond E.
core   +3 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

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