Results 41 to 50 of about 20,284 (217)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Square Root of a Multivector of Clifford Algebras in 3D: A Game with Signs
MathematicsAn algorithm is presented to extract the square root from a multivector (MV) in real Clifford algebras Clp,q, where n=p+q≤3, in radicals. It is shown that in Cl3,0, Cl1,2, and Cl0,3 algebras, there are up to four isolated square roots in a case of the ...
Arturas Acus, Adolfas Dargys
doaj +1 more source
International Journal for Computational Civil and Structural Engineering, 2019 Searching problem of shear stresses on outside longitudinal edges of an arbitrary cross-section (including open-closed multi-contour cross-sections) of a thin-walled bar subjected to the general load case has been considered in the paper.
Vitalina Yurchenko
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Jixie chuandong, 2008 Optimum tolerance design is one of important steps in the process of machine design and manufacture and in the application of computer,and model-building is an important step.Thus a kind of computer aided optimum tolerance design model is built,by the ...
张帆
doaj
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Studia Geotechnica et Mechanica, 2016 Computer Aided Engineering (CAE) is commonly used in modern design of the various types of structures. There are two main issues/aspects that should be consider while using CAE in Geotechnics: the basic theory and material model.
Borowiec Anna, Stanuszek Michał
doaj +1 more source