Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
A Computer Vision-assisted Approach to Automated Real-Time Road Infrastructure Management [PDF]
, 2022 Philippe Heitzmann
openalex +1 more source
An elementary way to rigorously estimate convergence to equilibrium and escape rates
, 2015 We show an elementary method to have (finite time and asymptotic) computer assisted explicit upper bounds on convergence to equilibrium (decay of correlations) and escape rate for systems satisfying a Lasota Yorke inequality.
Galatolo, Stefano +2 more
core +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Gold Nanoparticle-Based Breath Test Device for Rapid Detection of Infections
Current Directions in Biomedical EngineeringRespiratory tract infections represent a significant global health burden. We developed a gold nanoparticle-based breath test device that enables rapid detection of infections at the point-of-care.
Becke Sophie +8 more
doaj +1 more source
Computer assisted interactive resource scheduling system [PDF]
A computer system is reported that effectively schedules complex mission support by processing spacecraft requirements, station capabilities, and ephemeris data in teletype format ready for ...
Gustafson, C. E.
core +1 more source
Computer assisted modelling of linear, integer and separable programming problems [PDF]
, 1984 For mathematical programming (MP) to have greater impact upon the decision making process, MP software systems must offer suitable support in terms of model communication and modelling techniques .
Darby-Dowman, K, Lucas, CA, Mitra, G
core
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Current Directions in Biomedical Engineering, 2022 Gholami Bajestani Denis +4 more
doaj +1 more source
Factors associated with suboptimal adherence to antiretroviral therapy in Viet Nam: a cross-sectional study using audio computer-assisted self-interview (ACASI) [PDF]
, 2013 Hoa Do +4 more
openalex +1 more source