Results 101 to 110 of about 582,535 (300)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gold Nanoparticle-Based Breath Test Device for Rapid Detection of Infections

Current Directions in Biomedical Engineering
Respiratory tract infections represent a significant global health burden. We developed a gold nanoparticle-based breath test device that enables rapid detection of infections at the point-of-care.
Becke Sophie, Geus Paul, Bondzio Gabi, Schroer Jan, Froese Vera, Dernedde Jens, Kertzscher Ulrich, Bierewirtz Tim, Lommel Michael   +8 more
doaj   +1 more source

COMPUTER‐ASSISTED OBSERVER TRAINING [PDF]

Journal of Applied Behavior Analysis, 1987
Computerized interactive videotapes were used to train college students to use a 10‐second partial‐interval observational recording system. Students viewed videotapes and scored response occurrences on a computer keyboard. Incorrect scoring resulted in immediate computerized feedback and rescoring.Two independent variables, three versus seven target ...
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Hybrid polymer vessel phantoms for feasibility studies and clinical training of MRI-guided interventions

Current Directions in Biomedical Engineering, 2022
Gholami Bajestani Denis, Reich C. Martin, Mulik Christina, Mokosch Markus, Melzer Andreas   +4 more
doaj   +1 more source

Outcome of computer-assisted surgery in patients with chronic rhinosinusitis [PDF]

, 2017
Objective: To compare the complication rates and outcome of computer-assisted versus non-computer-assisted functional endoscopic sinus surgery. Methods: We reviewed retrospectively the medical records of 276 patients who had undergone sinus surgery for ...
Caversaccio, M., Mueller, S A.
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Computer assisted interactive resource scheduling system [PDF]

A computer system is reported that effectively schedules complex mission support by processing spacecraft requirements, station capabilities, and ephemeris data in teletype format ready for ...
Gustafson, C. E.
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

BiofilmQuant: A Computer-Assisted Tool for Dental Biofilm Quantification

, 2014
Dental biofilm is the deposition of microbial material over a tooth substratum. Several methods have recently been reported in the literature for biofilm quantification; however, at best they provide a barely automated solution requiring significant ...
Mansoor, Awais, Patsekin, Valery, Rajwa, Bartlomiej, Robinson, J. Paul, Scherl, Dale   +4 more
core   +1 more source