Results 101 to 110 of about 330,950 (237)

Some breathers and multi-breathers for FPU-type chains

open access: yes, 2018
We consider several breather solutions for FPU-type chains that have been found numerically. Using computer-assisted techniques, we prove that there exist true solutions nearby, and in some cases, we determine whether or not the solution is spectrally ...
Arioli, Gianni, Koch, Hans
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Towards a framework for standardized semantic workflow modeling and management in the surgical domain

open access: yesCurrent Directions in Biomedical Engineering, 2015
An essential aspect for workflow management support in operating room environments is the description and visualization of the underlying processes and activities in a machine readable format as Surgical Process Models (SPM).
Neumann Juliane, Neumuth Thomas
doaj   +1 more source

Computer-assisted design of organic synthesis [PDF]

open access: yes
The computer programs to design synthetic pathways of organic compounds have been utilized throughout the world since the first system was reported by Corey in 1969, and the LHASA was reported in1972 to become the predominant system.
Kaminaka, H.
core   +1 more source

Developing Computer-Assisted Tutorial Instructional Program for Teaching Grammar in Higher Education [PDF]

open access: yes, 2015
The aims of this research were to: (1) gain information on the existing condition of learning media which are used by lecturers to teach grammar, (2) develop the proper media which is suitable for the students' need and appropriate to teach grammar, and (
Asib, A. (Abdul)   +2 more
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Effective algorithm of analysis of integrability via the Ziglin's method

open access: yes, 2014
In this paper we continue the description of the possibilities to use numerical simulations for mathematically rigorous computer assisted analysis of integrability of dynamical systems.
AJ Maciejewski   +3 more
core   +2 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

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