Results 101 to 110 of about 576,672 (286)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Towards structuring contextual information for workflow-driven surgical assistance functionalities
Current Directions in Biomedical Engineering, 2015 A workflow-driven cooperative working environment needs to be established in order to successfully unburden the surgeon and the OR staff from technical configuration and information-seeking tasks.
Franke Stefan, Neumuth Thomas
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Goddard research and engineering management exercise /GREMEX/ [PDF]
Computer assisted management simulation exercise for training of personnel as project ...
Baker, R. F.
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Some breathers and multi-breathers for FPU-type chains
, 2018 We consider several breather solutions for FPU-type chains that have been found numerically. Using computer-assisted techniques, we prove that there exist true solutions nearby, and in some cases, we determine whether or not the solution is spectrally ...
Arioli, Gianni, Koch, Hans
core +1 more source
COMPUTER‐ASSISTED OBSERVER TRAINING [PDF]
Journal of Applied Behavior Analysis, 1987 Computerized interactive videotapes were used to train college students to use a 10‐second partial‐interval observational recording system. Students viewed videotapes and scored response occurrences on a computer keyboard. Incorrect scoring resulted in immediate computerized feedback and rescoring.Two independent variables, three versus seven target ...
openaire +2 more sources
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Current Directions in Biomedical Engineering, 2022 Gholami Bajestani Denis +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source