Results 141 to 150 of about 606,107 (335)

CHARACTERISTICS AND EVALUATION METHODS OF THE CASE TOOLS [PDF]

The acronym CASE – Computer Assisted Software Engineering – is the term used to indicate a collection of methods, tools and processes used in the development of software products with the assistance of the computer ...
Ionel Iacob
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Detection of flap malperfusion after microsurgical tissue reconstruction using hyperspectral imaging and machine learning

Scientific Reports
Hyperspectral imaging (HSI) has shown significant diagnostic potential for both intra- and postoperative perfusion assessment. The purpose of this study was to combine machine learning and neural networks with HSI to develop a method for detecting flap ...
Marianne Maktabi, Benjamin Huber, Toni Pfeiffer, Torsten Schulz   +3 more
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Recognition of the lumbar spine using MRI plane-based FiLM conditioning and patient dependent batching on semantic segmentation

Current Directions in Biomedical Engineering
Lower back pain (LBP) is a common symptom that can be linked to the degeneration of intervertebral discs or injuries to vertebrae. Accurate segmentation of lumbar spinal structures is vital for image-based surgery planning but can be resource intensive ...
Stelzner Tim, Baur David, Neumann Juliane, Berger Johann, Völker Anna, Heyde Christoph-E., Neumuth Thomas, Bieck Richard   +7 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

APLIKASI PEMBELAJARAN CITRA DENGAN MENGGUNAKAN METODE COMPUTER ASSISTED INSTRUCTION (CAI)

, 2016
Abdul Khair Tarigan, Surya Darma Nasution, Suginam Suginam, Abdul Karim   +3 more
openalex   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Shape optimisation of a ventricular assist device using a VADFEM computer program

, 2013
Magdalena Kopernik, Milenin, Andrzej
openalex   +1 more source

Relationship between the Superior Attachment Type of Uncinate Process and Presence of Agger Nasi Cell: A Computer‐Assisted Anatomic Study [PDF]

, 2006
İbrahim Ercan, Burak Ömür Çakır, İbrahim Sayın, Muzaffer Başak, Suat Turgut   +4 more
openalex   +1 more source