Results 151 to 160 of about 109,951 (299)

An empirical taxonomy of IS decision-making processes

open access: yes
Decisions to invest in information systems (IS) are made by many organisations on a very regular basis. Such decisions can vary from quickly identifying the problem, screening options and choosing a solution in a very straightforward way, to very ...
Boonstra, Albert
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Human-AI Interaction in Kidney Transplant Decision Support Systems: Qualitative Study of Patient and Support Person Expectations. [PDF]

open access: yesJ Med Internet Res
Sassi Z   +11 more
europepmc   +1 more source

The evolving role of the judge in digitally assisted adjudication

open access: yes
The thesis analyses the evolving role of the judge in digitally assisted adjudication. It proposes two novel roles and one adapted role for the human judge, named co-designer, integrator, and overseer or quality controller respectively.
Vanderstichele, Genevieve
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

E-mail and Direct Participation in Decision Making: A Literature Review

open access: yes
This paper reviews the literature on the effects of the use of e-mail on direct participation in decision making (PDM) in organisations. After a brief review of the organisational literature on participation the paper distinguishes e-mail theories on ...
Dandi, Roberto
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Artificial intelligence and the future of prosthodontics: a narrative review. [PDF]

open access: yesSaudi Dent J
Jayasheelan JA   +3 more
europepmc   +1 more source

Prosecutorial guidelines for voluntary euthanasia and assisted suicide : autonomy, public confidence and high quality decision-making

open access: yes, 2012
This article proposes offence-specific guidelines for how prosecutorial discretion should be exercised in cases of voluntary euthanasia and assisted suicide. Similar guidelines have been produced in England and Wales but we consider them to be deficient
Downie, Jocelyn   +2 more
core  

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

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