Results 111 to 120 of about 150,893 (291)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Video-assisted laparoscopy for the detection and diagnosis of endometriosis: safety, reliability, and invasiveness

, 2012
Erica Schipper,1 Camran Nezhat21Center for Minimally Invasive and Robotic Surgery, Palo Alto, CA; 2Obstetrics/Gynecology and Surgery, Stanford University Medical Center, Palo Alto, CA, USAAbstract: Endometriosis is a highly enigmatic disease with ...
Schipper E, Nezhat C
core  

Computer assisted assessment of progressing osteoradionecrosis of the jaw for clinical diagnosis and treatment

Current Directions in Biomedical Engineering, 2016
Osteoradionecrosis (ORN) is a serious side effect of oncologic radiation therapy. Often, surgical removal of the affected skeletal tissue is indicated. In cranio-maxillofacial surgery, partial or total resection of the upper or lower jaw implies a severe
Kober Cornelia, Kjeller Göran, Sader Robert, Zeilhofer Hans-Florian, Berg Britt-Isabelle   +4 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Automated Lung Cancer Segmentation in Tissue Micro Array Analysis Histopathological Images Using a Prototype of Computer-Assisted Diagnosis. [PDF]

J Pers Med, 2023
Althubaity DD, Alotaibi FF, Osman AMA, Al-Khadher MA, Abdalla YHA, Alwesabi SA, Abdulrahman EEH, Alhemairy MA.   +7 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Structured computer-assisted diagnosis of Mental Disorders [PDF]

, 2018
Zu berichten ist die Entwicklung und Erprobung eines Computerprogramms zur Diagnostik psychischer Störungen. Die Software ist in Zusammenarbeit mit dem Lehrstuhl für medizinische Informatik entstanden.
Holl, Michael Peter
core  

PatchCLIP enables region specific contrastive health record and image joint training with patch embedding loss

Scientific Reports
Vision-Language (VL) models such as Contrastive Language-Image pretraining (CLIP) have shown remarkable zero-shot classification capabilities by jointly learning from large-scale image–text datasets using multimodal self-supervised learning (SSL ...
Sheethal Bhat, Awais Mansoor, Bogdan Georgescu, Mathias Zinnen, Pranjal Sahu, Adarsh B. Panambur, Florin C. Ghesu, Sasa Grbic, Andreas Maier   +8 more
doaj   +1 more source

Application of Artificial Intelligence Computer-Assisted Diagnosis Originally Developed for Thyroid Nodules to Breast Lesions on Ultrasound. [PDF]

J Digit Imaging, 2022
Lee SE, Lee E, Kim EK, Yoon JH, Park VY, Youk JH, Kwak JY.   +6 more
europepmc   +1 more source