Head &Neck, EarlyView.ABSTRACT Objective To provide a comprehensive review of the biological rationale, clinical evidence, and practical perioperative management of immunotherapy for the head and neck surgeon. Summary Background Data Standard treatment for resectable head and neck squamous cell carcinoma (HNSCC) has reached a survival plateau, with over 50% of patients ...
Nicholas Brian Shannon, Bruce Ashford
wiley +1 more source
Superior Labial Artery Mucosal Flap (SLAM) for Reconstruction of Major Lower Lip Mucosal Defects
Head &Neck, EarlyView.ABSTRACT Background The superior labial artery mucosal (SLAM) flap is a versatile, pedicled axial flap ideally suited for mucosal lining in lower lip reconstruction. Methods This article details the surgical anatomy and technique of the SLAM flap, highlighting its role as a standalone liner or mucosal adjunct to microvascular free tissue transfer in ...
Nicholas Shannon +2 more
wiley +1 more source
Evaluation of dosimetric consistency between pre- and postoperative CT-guided noncoplanar template-assisted ¹²⁵I seed implantation in recurrent and metastatic thoracic tumors: a retrospective study. [PDF]
PeerJQiu L +11 more
europepmc +1 more source
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
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Machine learning in cancer imaging for enhanced precision in diagnosis and therapy. [PDF]
Discov ComputChow JCL.
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Living at genetic risk: The patient experience of Lynch syndrome
International Journal of Cancer, EarlyView.Abstract Lynch syndrome is a germline cancer predisposition syndrome caused by a variant in one of four genes. Lynch syndrome places individuals at significantly higher risk for a range of cancers, especially colorectal and endometrial. Depending on which gene is affected, the risk of ovarian, gastric, small bowel, pancreatic, biliary urothelial, brain,
Nicola Reents +2 more
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Cross-anatomical evaluation of a deep-learning auto-contouring system: qualitative, geometric, and dosimetric validation. [PDF]
J Appl Clin Med PhysEndo S +4 more
europepmc +1 more source
Association of Childhood Acute Leukemia With Autoimmune Diseases
International Journal of Cancer, EarlyView.A possible link exists between various pediatric autoimmune diseases (AIDs) and increased risk of childhood leukemia. Although immune dysregulation is a key feature of these conditions, the connection between them remains unclear. In this study, using cancer registry data in Finland, the authors examined associations between AIDs and childhood acute ...
Ida Pellikka +4 more
wiley +1 more source
Explicit modeling of beam geometry improves three-dimensional dose prediction for esophageal cancer radiotherapy under heterogeneous beam configurations. [PDF]
Radiat OncolDuan Y +10 more
europepmc +1 more source
International Journal of Cancer, EarlyView.Uncertainty has persisted over whether human papillomavirus (HPV) testing outperforms high‐quality cytology in real‐world cervical cancer screening programs. To address this, Denmark launched a nationwide trial in 2021, implementing an HPV‐based screening strategy using specialized algorithms integrated with molecular and cytology triage to optimize ...
Jesper Bonde +12 more
wiley +1 more source