Results 161 to 170 of about 6,097,409 (251)

MLH1 p.His112Arg Variant Is Associated With Increased Cancer Susceptibility

International Journal of Cancer, EarlyView.
ABSTRACT Lynch syndrome, a prevalent hereditary cancer predisposition, is frequently caused by pathogenic variants in the MutL homolog 1 (MLH1) mismatch repair gene. However, a significant proportion of MLH1 missense variants remain classified as variants of uncertain significance (VUS), creating clinical ambiguity.
Amal Elfatih, Issam Tout, Najwa Ahmad Doha, Tala Abu Arja, Idris Mohammed, Doua Abdelrhaman, Waseem Hasan, Chadi Saad, Hamdi Mbarek, Borbala Mifsud, Sahar Isa Da'as   +10 more
wiley   +1 more source

Commissioning a single photon counting CT simulator for radiotherapy planning: Methods, challenges, and initial results. [PDF]

J Appl Clin Med Phys
Basran PS, Richtsmeier D.
europepmc   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Real-world clinical impact of implementing and updating a deep learning-based automatic contouring system in rectal cancer radiotherapy. [PDF]

J Appl Clin Med Phys
Wang N, Xu T, Kang Y, Liang Y, Wang W, Nie W, Dai J, Tang Y, Men K.   +8 more
europepmc   +1 more source

Tissue Clearing for Lymph Nodes: 3D Mapping of Nerves and the Immune Microenvironment

iNew Medicine, EarlyView.
ABSTRACT Lymph nodes (LNs) are central hubs of adaptive immunity and key relay sites for metastatic tumour cells. However, conventional two‐dimensional histology samples only a small fraction of each node, potentially missing micrometastases and multifocal involvement while obscuring long‐range spatial relationships among tumour deposits, immune ...
Guang‐Hong Su, Fei Wang, Ting‐Hong Wei, Rui Lu, Wen‐Jun Huang, Xiang Zhang, Ling Yin, Jun Li   +7 more
wiley   +1 more source

Synthetic CT artifacts in MR-only brain radiotherapy: Clinical implementation experience. [PDF]

J Appl Clin Med Phys
Lee H, Ayan AS, Beyer S, Blakaj D, DiCostanzo D, Grecula JC, Palmer J, Raval R, Singh R, Thomas E, Weldon M, Yang X, Zoller W, Gupta N.   +13 more
europepmc   +1 more source

Comparison of Continuous‐Time Random Walk and Fractional Order Calculus Diffusion Models for Preoperative Breast Lesion Characterization: Diagnosis, Biomarker Prediction and Molecular Subtyping

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Accurate preoperative characterization of breast lesions is important for individualized management. The conventional monoexponential (Mono) model has limited ability to capture the complex microstructure of lesions. Non‐Gaussian diffusion models, including continuous‐time random walk (CTRW) and fractional‐order calculus (FROC), may
Yimeng Cao, Shaomin Li, Zhexuan Yang, Xueyan Liu, Shifang Tan, Tian Ren, Wenjia Wang, Haiyang Li, Xingzhi Chen, Xin Zhao, Meiying Cheng   +10 more
wiley   +1 more source

Pulmonary ventilation images from planning CT images using deep learning on locally-advanced NSCLC patients. [PDF]

J Appl Clin Med Phys
Katsuta Y, Hoshino T, Yamamoto T, Kadoya N, Tanaka S, Arai K, Umezawa R, Takahashi N, Jingu K.   +8 more
europepmc   +1 more source

MRI‐Derived Lymph Node Characteristics for Risk Stratification of Distant Metastasis in Locoregionally Advanced Nasopharyngeal Carcinoma

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background MRI‐derived nodal features may improve prognostication beyond TNM staging, but distant‐metastasis risk models remain limited. Purpose To develop and internally validate an MRI model for distant metastasis prediction in locoregionally advanced nasopharyngeal carcinoma (LA‐NPC). Study Type Retrospective.
Jing Wang, Yuxing Yu, Honghong Zhang, Haosheng Zhang, Jianxian Chen, Jiajia Zheng, Qisi Zhang, Hengyu Guo, Lanxin Lin, Yubin Hu, Sufang Qiu   +10 more
wiley   +1 more source

Advancing Tumor Treatment Through Artificial Intelligence and Mathematical Modeling: A Comprehensive Review. [PDF]

Health Sci Rep
Kamran M, Majeed A, Haque ASMR, Abdullah JY.   +3 more
europepmc   +1 more source