Results 91 to 100 of about 2,564,262 (308)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Employer\'s Exposure Risk to Electromagnetic Fields from Monitors of Computers in North of Iran

open access: yesمجله دانشگاه علوم پزشکی گرگان, 2021
Background and Objective: Overexposure to electromagnetic waves produces by computer cause health disorders by users. This study was performed to determine the employer's exposure risk to electromagnetic fields from monitors of computers in north of ...
Ali Shahryari   +3 more
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Gender Differences in the Association Between Screen Time and Depression

open access: yesAJPM Focus
Introduction: Previous research has shown that screen time is associated with depression, especially in children. Some evidence further suggests that the association may be stronger in women than in men, although findings are inconclusive.
Lauren E. Kleidermacher, MSc   +1 more
doaj   +1 more source

Computers and Computing in Society [PDF]

open access: yesNTM Zeitschrift für Geschichte der Wissenschaften, Technik und Medizin, 2020
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Beden Eğitimi Ve Spor Bölümü Öğrencilerinin Bilgisayar Kullanma Yeterlilikleri

open access: yesAkademik İncelemeler Dergisi, 2014
Bu çalışmanın amacı, Beden Eğitimi ve Spor Öğretmeni adaylarının günümüzün en önemli teknolojilerinden olan bilgisayar kullanım seviyelerini ortaya koymak ve çeşitli kriterlere göre farklılıkların olup olmadığının araştırılmasıdır.Araştırmada veriler ...
Çetin Yaman, Metin Yaman
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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