Results 131 to 140 of about 8,285,954 (300)

Objective Computation Versus Subjective Computation

open access: yesErkenntnis, 2014
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +4 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Beden Eğitimi Ve Spor Bölümü Öğrencilerinin Bilgisayar Kullanma Yeterlilikleri

open access: yesAkademik İncelemeler Dergisi, 2014
Bu çalışmanın amacı, Beden Eğitimi ve Spor Öğretmeni adaylarının günümüzün en önemli teknolojilerinden olan bilgisayar kullanım seviyelerini ortaya koymak ve çeşitli kriterlere göre farklılıkların olup olmadığının araştırılmasıdır.Araştırmada veriler ...
Çetin Yaman, Metin Yaman
doaj  

Gender Differences in the Association Between Screen Time and Depression

open access: yesAJPM Focus
Introduction: Previous research has shown that screen time is associated with depression, especially in children. Some evidence further suggests that the association may be stronger in women than in men, although findings are inconclusive.
Lauren E. Kleidermacher, MSc   +1 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Dreptul la protecţia datelor cu caracter personal: esenţă şi conţinut [PDF]

open access: yesRevista Institutului Naţional de Justiţie, 2014
The data protection right: essence and content Starting from the idea to prevent the apparition and development of confusion in use and in interpretation of data protection norms, by this article, we proposed to establish the limits of data ...
Mocanu Veronica
doaj  

Computational Neuroscience [PDF]

open access: yesComputational and Mathematical Methods in Medicine, 2014
Jinde Cao   +5 more
openaire   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

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