Results 161 to 170 of about 2,564,262 (308)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Social threats caused by artificial intelligence and society’s response to them

Studia Humanitatis
Artificial intelligence (AI) has become a reality of our lives and is used in all fields of human activity. An important problem associated with AI and actively being developed in science and culture today is the problem of potential threats that in the ...
Krylova Maria Nikolaevna
doaj  

Determinants of digital health literacy among health professionals: Evidence from public and private hospitals in Eastern Ethiopia. [PDF]

PLoS One
Asfaw E, Shiferaw T, Tolera M, Weldesenbet AB, Seid M.   +4 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Correction: Abushark et al. Optimized Adaboost Support Vector Machine-Based Encryption for Securing IoT-Cloud Healthcare Data. <i>Sensors</i> 2025, <i>25</i>, 731. [PDF]

Sensors (Basel)
Abushark YB, Hassan S, Khan AI.
europepmc   +1 more source

EVELOPMENT SMART TRAFFIC LIGHT CONTROL SYSTEM (STLCS) USING THE YOLO OBJECT DETECTION MODEL: AN IMPERATIVE FOR COMPUTER LOGIC EDUCATION

openalex   +1 more source

Ergo: A Gesture-Based Computer Interaction Device

, 2023
Boyd Robert Kane
openalex   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Impact of Different Types of Sedentary Behaviour on Cognitive Function in Older Adults: A Systematic Review. [PDF]

Health Promot J Austr
de Jesus Silva TR, Damião EP, Barbosa VS, de Matos Alcantara L, Dos Santos RG, Junior JSV.   +5 more
europepmc   +1 more source

Analog Computer Understanding of Hamiltonian Paths. [PDF]

, 2015
Bryce M. Kim
openalex