Results 91 to 100 of about 21,987 (211)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Enhancing Control of Built Assets through Computer Aided Design - Past, Present and Emerging Trends [PDF]

, 2010
This paper presents the trends in Computer aided drafting and design within the Architecture, Engineering, Construction and Operations (AECO) industry by examining past, present and emerging technologies, standards, deliverables and stakeholders involved.
Oommen, C.
core  

Analysis of Milling Performance of High-Entropy Alloys with Different Elemental Ratios Subject to the Assistance of Various Ultrasonic Systems

Applied Sciences
High-entropy alloys (HEAs) possess multi-element composition and uniform structure, exhibiting superior microstructure and properties compared to traditional alloys. However, the multi-element composition of HEAs results in a complex internal composition
Shen-Yung Lin, Bo-Chun Chen
doaj   +1 more source

Time for a New Class of Methods and Computer Aided Tools to Address the Challenges Facing Us?

Chemical Engineering Transactions, 2018
This paper highlights the need for a new class of computer aided tools applicable for a wide range of chemicals-based product synthesis-design and the sustainable design of their corresponding manufacturing processes. The new tools are needed to meet the
Anjan K Tula, Mario R. Eden, Rafiqul Gani   +2 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

A determination and classification of student errors in lower-level calculus through computer-aided assessment and analysis

, 2011
This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel University.This thesis describes the determination of student errors through paper-based assessment through to computer-aided assessment.
Hanson, James
core  

Computer-Aided Conceptual Design Through TRIZ-based Manipulation of Topological Optimizations [PDF]

, 2009
Organised by: Cranfield UniversityIn a recent project the authors proposed the adoption of Optimization Systems [1] as a bridging element between Computer-Aided Innovation (CAI) and PLM to identify geometrical contradictions [2], a particular case of ...
Cascini, G., Frillici, F. S., Rotini, F., Cugini, U.   +3 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Computer Aided Engineering of Cyber-Physical Information Gathering and Utilizing Systems [PDF]

Journal of Systemics, Cybernetics and Informatics, 2012
Engineering Cyber-physical information gathering and utilizing systems(CIGUS) presents the systems engineer with a difficult, multi-criterion, multi-objective decision problem.
Alfred P. Defonzo, Anthony P. Hopf
doaj